caa a22 4500 605538492 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2835-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2835-7 Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment [Elektronische Daten] [T. Khaliullin, A. Shvedova, E. Kisin, R. Zalyalov, L. Fatkhutdinova] Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers. Springer Science+Business Media New York, 2015 carbon nanotubes nationallicence in vivo nationallicence fibrosis nationallicence bronchoalveolar lavage nationallicence Khaliullin T. Kazan State Medical University, Kazan, Russia aut Shvedova A. National Institute for Occupational Safety and Health, Morgantown, USA aut Kisin E. National Institute for Occupational Safety and Health, Morgantown, USA aut Zalyalov R. Kazan State Medical University, Kazan, Russia aut Fatkhutdinova L. Kazan State Medical University, Kazan, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 684-687 0007-4888 158:5<684 2015 158 10517 https://doi.org/10.1007/s10517-015-2835-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2835-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Khaliullin T. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Shvedova A. National Institute for Occupational Safety and Health, Morgantown, USA aut NATIONALLICENCE 700 1- Kisin E. National Institute for Occupational Safety and Health, Morgantown, USA aut NATIONALLICENCE 700 1- Zalyalov R. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Fatkhutdinova L. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 684-687 0007-4888 158:5<684 2015 158 10517