caa a22 4500 605538549 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2820-1 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2820-1 Levocarnitine Normalizes Elevated Blood Level of Soluble Fas mRNA in Patients with Acute Myocardial Infarction [Elektronische Daten] [D. Novikov, S. Belousov, A. Karaulov, N. Eroshevskaya, S. Shumilova, E. Kasatova, Zh. Kazatskaya, V. Novikov] Fas-induced apoptosis plays an important role in the mechanisms of tissue injury in myocardial infarction. The level of membrane Fas mRNA was elevated during the postinfarction period in the blood of patients and did not change in response to levocarnitine. The mRNA level of soluble Fas, inhibiting Fas-dependent apoptosis, remained normal during the first 7 days, but increased 14 days after myocardial infarction, which corresponded to previously detected increase of serum level of soluble Fas molecules. Addition of levocarnitine, inhibiting Fas-dependent apoptosis, to therapy caused no changes in the level of soluble Fas mRNA, presumably because of similar effects of soluble Fas and levocarnitine on the apoptotic processes in myocardial infarction. Springer Science+Business Media New York, 2015 apoptosis nationallicence myocardial infarction nationallicence soluble Fas mRNA nationallicence Novikov D. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut Belousov S. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia aut Karaulov A. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut Eroshevskaya N. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia aut Shumilova S. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut Kasatova E. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut Kazatskaya Zh N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut Novikov V. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 617-620 0007-4888 158:5<617 2015 158 10517 https://doi.org/10.1007/s10517-015-2820-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2820-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Novikov D. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Belousov S. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Karaulov A. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Eroshevskaya N. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Shumilova S. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Kasatova E. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Kazatskaya Zh N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut NATIONALLICENCE 700 1- Novikov V. N. I. Lobachevsky Nizhny Novgorod State University, Nizhny Novgorod, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 617-620 0007-4888 158:5<617 2015 158 10517