caa a22 4500 605538557 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2819-7 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2819-7 Study on Activity of Infl ammatory Factors in Patients with Chronic Heart Failure Depending on the Stage of the Disease and NYHA Class [Elektronische Daten] [E. Trofimov, A. Poskrebysheva] The levels of IL-8 and IL-10 and their ratio depending on the stage and NYHA functional class of heart failure were determined in the patients with chronic heart failure in comparison with healthy individuals. The level of IL-8 and IL-8/IL-10 ratio in patients were significantly higher than in controls, and the level of IL-10, significantly lower. The comparison of cytokine levels in patients at different stages of heart failure and NYHA class revealed no significant differences. However, the level of IL-10 tended to decrease by stage 3 of the disease. Significantly elevated IL-8 level along with reduced IL-10 level and significantly increased IL-8/IL-10 ratio indicated predominance of proinflammatory activity in patients with chronic heart failure, which along with the tendency to decrease IL-10 level at stage 3 of the disease may indicate the ineffectiveness of compensatory mechanisms and progressive "failure” of compensation with increasing severity of the disease. Springer Science+Business Media New York, 2015 chronic heart failure nationallicence interleukin-8 nationallicence interleukin-10, cytokines nationallicence NYHA class of heart failure nationallicence Trofimov E. A. I. Nesterov Department of Faculty Therapy, N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia aut Poskrebysheva A. A. I. Nesterov Department of Faculty Therapy, N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 614-616 0007-4888 158:5<614 2015 158 10517 https://doi.org/10.1007/s10517-015-2819-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2819-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trofimov E. A. I. Nesterov Department of Faculty Therapy, N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia aut NATIONALLICENCE 700 1- Poskrebysheva A. A. I. Nesterov Department of Faculty Therapy, N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 614-616 0007-4888 158:5<614 2015 158 10517