caa a22 4500 605538565 CHVBK 20210128100902.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2830-z doi (NATIONALLICENCE)springer-10.1007/s10517-015-2830-z Afobazole Protects Rats Exposed to Peat Smoke In Utero [Elektronische Daten] [D. Gorbatova, S. Litvinova, A. Durnev, S. Seredenin] Female outbred albino rats were daily subjected to forced inhalations of peat smoke (4 cores packed with a mixture of peat (70%) and wood pulp (30%); 0.46 g, pH at least 5.5, core burning time 6 min,; total exposure 44 min) per se and in combination with oral afobazole (anxiolytic) in doses of 1 and 10 mg/kg on days 1-20 of pregnancy. Some groups of females received oral afobazole (200 mg/kg) after delivery, due to which their newborn rats received the drug in doses of 1-10 mg/kg with maternal milk on days 1-20 of life. Exposure to peat smoke inhibited body weight gain in the progeny on days 5-60 of life. Afobazole treatment during the pre- and postnatal periods prevented this effect. Open field testing showed that exposure to peat smoke prolonged the motor activity in the progeny and impaired the loss of orientation and exploratory behavior during repeated testing. Oral afobazole (1 and 10 mg/kg) during the prenatal and/or postnatal period (with maternal milk) prevented the effects of peat smoke. Springer Science+Business Media New York, 2015 peat smoke nationallicence prenatal period nationallicence behavior nationallicence open-field test nationallicence afobazole nationallicence Gorbatova D. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Litvinova S. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Durnev A. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Seredenin S. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 664-669 0007-4888 158:5<664 2015 158 10517 https://doi.org/10.1007/s10517-015-2830-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2830-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gorbatova D. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 700 1- Litvinova S. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 700 1- Durnev A. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 700 1- Seredenin S. Laboratory of Drug Toxicology, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 664-669 0007-4888 158:5<664 2015 158 10517