Serum Levels of Neurosteroids in Patients with Affective Disorders
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2825-9 |2 doi |
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| 245 | 0 | 0 | |a Serum Levels of Neurosteroids in Patients with Affective Disorders |h [Elektronische Daten] |c [L. Levchuk, N. Vyalova, S. Ivanova, G. Simutkin, E. Lebedeva, N. Bokhan] |
| 520 | 3 | |a According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic-pituitary-adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced defi ciency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic-pituitary-adrenal system in affective disorders. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a affective disorders |2 nationallicence | |
| 690 | 7 | |a dehydroepiandrosterone |2 nationallicence | |
| 690 | 7 | |a dehydroepiandrosterone sulfate |2 nationallicence | |
| 700 | 1 | |a Levchuk |D L. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Vyalova |D N. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Ivanova |D S. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Simutkin |D G. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Lebedeva |D E. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 700 | 1 | |a Bokhan |D N. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 638-640 |x 0007-4888 |q 158:5<638 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2825-9 |q text/html |z Onlinezugriff via DOI |
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| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2825-9 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Levchuk |D L. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Vyalova |D N. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ivanova |D S. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Simutkin |D G. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Lebedeva |D E. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bokhan |D N. |u Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 638-640 |x 0007-4888 |q 158:5<638 |1 2015 |2 158 |o 10517 | ||