caa a22 4500 60553859X CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2825-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2825-9 Serum Levels of Neurosteroids in Patients with Affective Disorders [Elektronische Daten] [L. Levchuk, N. Vyalova, S. Ivanova, G. Simutkin, E. Lebedeva, N. Bokhan] According modern biological hypotheses of the pathogenesis of affective disorders, hypothalamic-pituitary-adrenal axis dysfunction play a special role in the pathogenesis of this condition. Our study shows that the range of neuroprotective neurosteroids is gender- and nosology-dependent. Patients with affective disorders have reduced levels of dehydroepiandrosterone and dehydroepiandrosterone sulfate; the most pronounced defi ciency of neuroprotective neurosteroids is typical of patients with a single depressive episode. Reduced levels of neurosteroids producing an anabolic effect probably indicate depletion of adaptive capacities of the hypothalamic-pituitary-adrenal system in affective disorders. Springer Science+Business Media New York, 2015 affective disorders nationallicence dehydroepiandrosterone nationallicence dehydroepiandrosterone sulfate nationallicence Levchuk L. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut Vyalova N. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut Ivanova S. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut Simutkin G. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut Lebedeva E. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut Bokhan N. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 638-640 0007-4888 158:5<638 2015 158 10517 https://doi.org/10.1007/s10517-015-2825-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2825-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levchuk L. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Vyalova N. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Ivanova S. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Simutkin G. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Lebedeva E. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 700 1- Bokhan N. Mental Health Research Institute, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 638-640 0007-4888 158:5<638 2015 158 10517