Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2812-1 |2 doi |
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| 245 | 0 | 0 | |a Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats |h [Elektronische Daten] |c [N. Bogdanova, A. Kolpakov, S. Sudakov] |
| 520 | 3 | |a We studied the effect of intragastric administration of peptide agonists of μ-opioid receptors (DAMGO) and δ-opioid receptors (DADLE) on food consumption and food motivation during operant feeding behavior of different intensity and effectiveness. To obtain one food granule, trained rats should press a lever 1 time (day 1), 2 times (day 2), 4 times (day 3), 8 times (day 4), 16 times (day 5), or 32 times (day 6). Activation of δ-opioid receptors in the stomach was followed by suppression of feeding behavior at low energy expenditure. The level of food motivation under these conditions practically did not differ from the control. Activation of μ-opioid receptors in the stomach suppressed energy-consuming feeding behavior, which was accompanied by an increase in the level of food motivation. It can be hypothesized that protein metabolites exhibiting μ-opioid activity probably provide afferent signals into CNS via the vagus nerve to terminate energy expenditure under adverse conditions (although food motivation is not satisfied). Food motivation under these conditions probably contributes to the behavior aimed towards the search for more available food. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a peripheral μ- and δ-opioid receptors |2 nationallicence | |
| 690 | 7 | |a operant feeding behavior |2 nationallicence | |
| 690 | 7 | |a level of food motivation |2 nationallicence | |
| 690 | 7 | |a rats |2 nationallicence | |
| 700 | 1 | |a Bogdanova |D N. |u P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Kolpakov |D A. |u P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia |4 aut | |
| 700 | 1 | |a Sudakov |D S. |u P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 589-591 |x 0007-4888 |q 158:5<589 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2812-1 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2812-1 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Bogdanova |D N. |u P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kolpakov |D A. |u P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Sudakov |D S. |u P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 589-591 |x 0007-4888 |q 158:5<589 |1 2015 |2 158 |o 10517 | ||