caa a22 4500 605538603 CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2812-1 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2812-1 Effect of Peptide Agonists of Peripheral Opioid Receptors on Operant Feeding Behavior and Food Motivation in Rats [Elektronische Daten] [N. Bogdanova, A. Kolpakov, S. Sudakov] We studied the effect of intragastric administration of peptide agonists of μ-opioid receptors (DAMGO) and δ-opioid receptors (DADLE) on food consumption and food motivation during operant feeding behavior of different intensity and effectiveness. To obtain one food granule, trained rats should press a lever 1 time (day 1), 2 times (day 2), 4 times (day 3), 8 times (day 4), 16 times (day 5), or 32 times (day 6). Activation of δ-opioid receptors in the stomach was followed by suppression of feeding behavior at low energy expenditure. The level of food motivation under these conditions practically did not differ from the control. Activation of μ-opioid receptors in the stomach suppressed energy-consuming feeding behavior, which was accompanied by an increase in the level of food motivation. It can be hypothesized that protein metabolites exhibiting μ-opioid activity probably provide afferent signals into CNS via the vagus nerve to terminate energy expenditure under adverse conditions (although food motivation is not satisfied). Food motivation under these conditions probably contributes to the behavior aimed towards the search for more available food. Springer Science+Business Media New York, 2015 peripheral μ- and δ-opioid receptors nationallicence operant feeding behavior nationallicence level of food motivation nationallicence rats nationallicence Bogdanova N. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Kolpakov A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Sudakov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 589-591 0007-4888 158:5<589 2015 158 10517 https://doi.org/10.1007/s10517-015-2812-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2812-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bogdanova N. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Kolpakov A. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 700 1- Sudakov S. P. K. Anokhin Research Institute of Normal Physiology, Moscow, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 589-591 0007-4888 158:5<589 2015 158 10517