caa a22 4500 605538638 CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2833-9 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2833-9 Expression of Vascular Endothelial Growth Factor (VEGF-A) in Rat Mandibular Salivary Gland during Paraneoplastic Process and Treatment with Cyclophosphamide and Melatonin [Elektronische Daten] [E. Ovsyanko, A. Kulishenko, E. Lushnikova, A. Vinogradov, I. Zhurakovskii, M. Pustovetova, Ya. Ovsyanko] Expression of VEGF-A in Walker 256 carcinosarcoma and mandibular salivary gland of rats during paraneoplastic process and various regimens of chemotherapy with melatonin and cyclophosphamide were studied by immunohistochemical methods. VEGF-A expression increased in the tumor node and salivary gland after monotherapy with melatonin and cyclophosphamide during progression of tumor growth and paraneoplastic syndrome. A decrease in VEGF-A expression in the tumor node and salivary gland was found after monotherapy with melatonin and cyclophosphamide and, especially, after combined treatment, which proves maximum therapeutic efficiency of combined administration of chemical agents with various mechanisms of action. Overexpression of VEGF-A in the mandibular salivary gland can have diagnostic and predictive value in early diagnostics of neoplasms. Springer Science+Business Media New York, 2015 Walker 256 carcinosarcoma nationallicence vascular endothelial growth factor nationallicence mandibular salivary gland nationallicence melatonin nationallicence cyclophosphamide nationallicence Ovsyanko E. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Kulishenko A. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Lushnikova E. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia aut Vinogradov A. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Zhurakovskii I. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Pustovetova M. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Ovsyanko Ya Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 676-680 0007-4888 158:5<676 2015 158 10517 https://doi.org/10.1007/s10517-015-2833-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2833-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ovsyanko E. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Kulishenko A. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Lushnikova E. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Vinogradov A. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Zhurakovskii I. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Pustovetova M. Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Ovsyanko Ya Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 676-680 0007-4888 158:5<676 2015 158 10517