Nootropic Effect of Meadowsweet ( Filipendula vulgaris ) Extracts

Verfasser / Beitragende:
[I. Shilova, N. Suslov]
Ort, Verlag, Jahr:
2015
Enthalten in:
Bulletin of Experimental Biology and Medicine, 158/5(2015-03-01), 659-663
Format:
Artikel (online)
ID: 605538646
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024 7 0 |a 10.1007/s10517-015-2841-9  |2 doi 
035 |a (NATIONALLICENCE)springer-10.1007/s10517-015-2841-9 
245 0 0 |a Nootropic Effect of Meadowsweet ( Filipendula vulgaris ) Extracts  |h [Elektronische Daten]  |c [I. Shilova, N. Suslov] 
520 3 |a The effects of the extracts of the aboveground parts of Filipendula vulgaris Moench on the behavior and memory of mice after hypoxic injury and their physical performance in the open-field test were studied using the models of hypoxia in a sealed volume, conditioned passive avoidance response (CPAR), and forced swimming with a load. The extracts improved animal resistance to hypoxia, normalized orientation and exploration activities, promoted CPAR retention after hypoxic injury, and increased physical performance. Aqueous extract of meadowsweet had the most pronounced effect that corresponded to the effect of the reference drug piracetam. These effects were probably caused by modulation of hippocampal activity. 
540 |a Springer Science+Business Media New York, 2015 
690 7 |a Filipendula vulgaris Moench  |2 nationallicence 
690 7 |a conditioned passive avoidance response  |2 nationallicence 
690 7 |a open-field test  |2 nationallicence 
690 7 |a hypoxia, forced swimming  |2 nationallicence 
700 1 |a Shilova  |D I.  |u E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia  |4 aut 
700 1 |a Suslov  |D N.  |u E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia  |4 aut 
773 0 |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 158/5(2015-03-01), 659-663  |x 0007-4888  |q 158:5<659  |1 2015  |2 158  |o 10517 
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950 |B NATIONALLICENCE  |P 700  |E 1-  |a Shilova  |D I.  |u E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 700  |E 1-  |a Suslov  |D N.  |u E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia  |4 aut 
950 |B NATIONALLICENCE  |P 773  |E 0-  |t Bulletin of Experimental Biology and Medicine  |d Springer US; http://www.springer-ny.com  |g 158/5(2015-03-01), 659-663  |x 0007-4888  |q 158:5<659  |1 2015  |2 158  |o 10517