caa a22 4500 605538654 CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2823-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2823-y Effectiveness of Composition Based on Oxidized Dextran in the Treatment of Grade IIIB Skin Burns [Elektronische Daten] [V. Shkurupy, M. Karpov, A. Troitskii, S. Arkhipov, D. Neshchadim] Grade IIIB skin burns were treated with a composition based on oxidized dextran with a molecular weight of 40 kDa (oxidation of 7% glucose residues). On day 32 after burn infliction and from the start of the treatment, the area of skin defect in rats was 30% less than in the group without treatment and by 2.3 times less than in rats treated with panthenol. In rats treated with dextran-based composition or panthenol, the eschar was absent on day 21 after the start of the treatment; by day 32, we found cells of surface epithelium, hair follicles, and sebaceous glands above the scar tissue that were absent in untreated animals; in rats treated with the composition, their number was higher by 2.5 times than in animals treated with panthenol. Treatment with the composition increased volume density (by 2.5 times) and numerical density (by more than 3 times) of blood vessels in the wound and reduced signs of inflammation and fibroplastic activity of fibroblasts in comparison with the corresponding parameters in untreated animals or animals treated with panthenol. Springer Science+Business Media New York, 2015 burn nationallicence oxidized dextran nationallicence reparative regeneration nationallicence skin nationallicence Shkurupy V. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Karpov M. Novosibirsk State Medical University, Novosibirsk, Russia aut Troitskii A. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Arkhipov S. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Neshchadim D. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 628-631 0007-4888 158:5<628 2015 158 10517 https://doi.org/10.1007/s10517-015-2823-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2823-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shkurupy V. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Karpov M. Novosibirsk State Medical University, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Troitskii A. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Arkhipov S. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Neshchadim D. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 628-631 0007-4888 158:5<628 2015 158 10517