Changes in Electrical Activity of Working Myocardium Under Condition of If Current Inhibition
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| 024 | 7 | 0 | |a 10.1007/s10517-015-2815-y |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2815-y | ||
| 245 | 0 | 0 | |a Changes in Electrical Activity of Working Myocardium Under Condition of If Current Inhibition |h [Elektronische Daten] |c [D. Abramochkin, L. Faskhutdinov, T. Filatova, N. Ziyatdinova] |
| 520 | 3 | |a The study examined the effect of ZD7288, a blocker of hyperpolarization-activated "funny” current If, on electrical activity in working atrial and ventricular myocardium in rats. In concentrations range from 3×10-6 to 3×10-5 M, the agent significantly increased the duration of action potentials at 50 and 90% repolarization levels in both atrial and ventricular myocardium at the fixed stimulation rate of 5 Hz. The blocker affected neither resting potential nor the upstroke velocity of action potential. In patch-clamp experiments, ZD7288 selectively inhibited If current, but produced no effect on delayed rectifier potassium currents that determine the rate of repolarization. The described effects of ZD7288 are not related to its non-specific effects on the ionic currents except If. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a If current |2 nationallicence | |
| 690 | 7 | |a atrium |2 nationallicence | |
| 690 | 7 | |a action potential |2 nationallicence | |
| 690 | 7 | |a ionic currents |2 nationallicence | |
| 700 | 1 | |a Abramochkin |D D. |u Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Faskhutdinov |D L. |u Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Filatova |D T. |u Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | |
| 700 | 1 | |a Ziyatdinova |D N. |u Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 600-603 |x 0007-4888 |q 158:5<600 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2815-y |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2815-y |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Abramochkin |D D. |u Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Faskhutdinov |D L. |u Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Filatova |D T. |u Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ziyatdinova |D N. |u Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 600-603 |x 0007-4888 |q 158:5<600 |1 2015 |2 158 |o 10517 | ||