caa a22 4500 605538662 CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2815-y doi (NATIONALLICENCE)springer-10.1007/s10517-015-2815-y Changes in Electrical Activity of Working Myocardium Under Condition of If Current Inhibition [Elektronische Daten] [D. Abramochkin, L. Faskhutdinov, T. Filatova, N. Ziyatdinova] The study examined the effect of ZD7288, a blocker of hyperpolarization-activated "funny” current If, on electrical activity in working atrial and ventricular myocardium in rats. In concentrations range from 3×10-6 to 3×10-5 M, the agent significantly increased the duration of action potentials at 50 and 90% repolarization levels in both atrial and ventricular myocardium at the fixed stimulation rate of 5 Hz. The blocker affected neither resting potential nor the upstroke velocity of action potential. In patch-clamp experiments, ZD7288 selectively inhibited If current, but produced no effect on delayed rectifier potassium currents that determine the rate of repolarization. The described effects of ZD7288 are not related to its non-specific effects on the ionic currents except If. Springer Science+Business Media New York, 2015 If current nationallicence atrium nationallicence action potential nationallicence ionic currents nationallicence Abramochkin D. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Faskhutdinov L. Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia aut Filatova T. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut Ziyatdinova N. Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 600-603 0007-4888 158:5<600 2015 158 10517 https://doi.org/10.1007/s10517-015-2815-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2815-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abramochkin D. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Faskhutdinov L. Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia aut NATIONALLICENCE 700 1- Filatova T. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia aut NATIONALLICENCE 700 1- Ziyatdinova N. Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 600-603 0007-4888 158:5<600 2015 158 10517