Dynamics of Behavioral Disorders in Transgenic Mice with Modeled Alzheimer's Disease
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605538689 | ||
| 003 | CHVBK | ||
| 005 | 20210128100903.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20150301xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10517-015-2821-0 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10517-015-2821-0 | ||
| 245 | 0 | 0 | |a Dynamics of Behavioral Disorders in Transgenic Mice with Modeled Alzheimer's Disease |h [Elektronische Daten] |c [I. Semina, A. Baichurina, E. Makarova, A. Leushina, Zh. Kazakevich, M. Gabdrakhmanova, M. Mukhamed'yarov, A. Zefirov] |
| 520 | 3 | |a Age-related development of behavioral disorders in transgenic mice with modeled Alzheimer's disease carrying V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) genotype was assessed at the age of 7.5, 10 and 20 months in the following tests: open-field, plus maze, T-maze, conditioned passive avoidance response, rotarod, conflict situation with water deprivation, behavioral despair, and arecoline tremor. The main behavioral disorder in transgenic mice at all observation terms was memory impairment in conditioning with positive (but not negative) reinforcement. At the age of 7.5 and 10 months, transgenic mice also showed signs of nonspecific excitement and anxiety, depression-like state, and symptoms of cholinergic deficit. Our results suggest that appropriate age for behavioral tests in studies of effects of potential anti-Alzheimer drugs in transgenic V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) mice is 7.5-10 months. | |
| 540 | |a Springer Science+Business Media New York, 2015 | ||
| 690 | 7 | |a Alzheimer's disease |2 nationallicence | |
| 690 | 7 | |a transgenic mice |2 nationallicence | |
| 690 | 7 | |a behavioral tests |2 nationallicence | |
| 690 | 7 | |a memory disturbances |2 nationallicence | |
| 700 | 1 | |a Semina |D I. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Baichurina |D A. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Makarova |D E. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Leushina |D A. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Kazakevich |D Zh |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Gabdrakhmanova |D M. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Mukhamed'yarov |D M. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 700 | 1 | |a Zefirov |D A. |u Kazan State Medical University, Kazan, Russia |4 aut | |
| 773 | 0 | |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 621-623 |x 0007-4888 |q 158:5<621 |1 2015 |2 158 |o 10517 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10517-015-2821-0 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10517-015-2821-0 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Semina |D I. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Baichurina |D A. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Makarova |D E. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Leushina |D A. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kazakevich |D Zh |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Gabdrakhmanova |D M. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Mukhamed'yarov |D M. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zefirov |D A. |u Kazan State Medical University, Kazan, Russia |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Bulletin of Experimental Biology and Medicine |d Springer US; http://www.springer-ny.com |g 158/5(2015-03-01), 621-623 |x 0007-4888 |q 158:5<621 |1 2015 |2 158 |o 10517 | ||