caa a22 4500 605538689 CHVBK 20210128100903.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s10517-015-2821-0 doi (NATIONALLICENCE)springer-10.1007/s10517-015-2821-0 Dynamics of Behavioral Disorders in Transgenic Mice with Modeled Alzheimer's Disease [Elektronische Daten] [I. Semina, A. Baichurina, E. Makarova, A. Leushina, Zh. Kazakevich, M. Gabdrakhmanova, M. Mukhamed'yarov, A. Zefirov] Age-related development of behavioral disorders in transgenic mice with modeled Alzheimer's disease carrying V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) genotype was assessed at the age of 7.5, 10 and 20 months in the following tests: open-field, plus maze, T-maze, conditioned passive avoidance response, rotarod, conflict situation with water deprivation, behavioral despair, and arecoline tremor. The main behavioral disorder in transgenic mice at all observation terms was memory impairment in conditioning with positive (but not negative) reinforcement. At the age of 7.5 and 10 months, transgenic mice also showed signs of nonspecific excitement and anxiety, depression-like state, and symptoms of cholinergic deficit. Our results suggest that appropriate age for behavioral tests in studies of effects of potential anti-Alzheimer drugs in transgenic V6S3-Tg(APP695)85Dbo Tg(PSENI)85Dbo) mice is 7.5-10 months. Springer Science+Business Media New York, 2015 Alzheimer's disease nationallicence transgenic mice nationallicence behavioral tests nationallicence memory disturbances nationallicence Semina I. Kazan State Medical University, Kazan, Russia aut Baichurina A. Kazan State Medical University, Kazan, Russia aut Makarova E. Kazan State Medical University, Kazan, Russia aut Leushina A. Kazan State Medical University, Kazan, Russia aut Kazakevich Zh Kazan State Medical University, Kazan, Russia aut Gabdrakhmanova M. Kazan State Medical University, Kazan, Russia aut Mukhamed'yarov M. Kazan State Medical University, Kazan, Russia aut Zefirov A. Kazan State Medical University, Kazan, Russia aut Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 621-623 0007-4888 158:5<621 2015 158 10517 https://doi.org/10.1007/s10517-015-2821-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10517-015-2821-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Semina I. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Baichurina A. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Makarova E. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Leushina A. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Kazakevich Zh Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Gabdrakhmanova M. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Mukhamed'yarov M. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 700 1- Zefirov A. Kazan State Medical University, Kazan, Russia aut NATIONALLICENCE 773 0- Bulletin of Experimental Biology and Medicine Springer US; http://www.springer-ny.com 158/5(2015-03-01), 621-623 0007-4888 158:5<621 2015 158 10517