caa a22 4500 605539227 CHVBK 20210128100905.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10396-014-0573-5 doi (NATIONALLICENCE)springer-10.1007/s10396-014-0573-5 The arrhythmogenic effect of ultrasonic exposure with acoustic radiation force (ARF) impulse on the rabbit heart with ultrasound contrast agent perfluorobutane [Elektronische Daten] [Yasunao Ishiguro, Hideki Sasanuma, Naotaka Nitta, Nobuyuki Taniguchi, Yukiyo Ogata, Yoshikazu Yasuda, Iwaki Akiyama] Purpose: Acoustic radiation force (ARF) impulse can be used to estimate the elasticity of cardiac muscle. The purpose of this study was to evaluate the effect of ARF on the heart with concomitant administration of the ultrasound contrast agent (UCA) perfluorobutane for recently developed elasticity imaging such as shear wave imaging. Methods: Ultrasound with ARF was applied to the heart of Japanese white rabbit with or without UCA administration. During the exposure, electrocardiographs were recorded. Results: Following the exposure of ultrasound with a duration of 10ms and a mechanical index (MI) of 4.0 to the heart, extra waves (QRS complex) were observed only after UCA administration. Although life-threatening arrhythmia was not observed, a greater increase in the frequency of the extra waves was observed following a drip infusion compared with a single (bolus) UCA infusion. In addition, 16.3% of extra waves were followed by arterial pressure pulse. Conclusions: Cardiac ultrasound with higher MI and longer duration should be carefully considered, particularly with the concomitant use of UCA and higher MI. The Japan Society of Ultrasonics in Medicine, 2014 Acoustic radiation force nationallicence Ultrasound contrast agent nationallicence Heart nationallicence Rabbit nationallicence Arrhythmia nationallicence Long duration nationallicence High MI nationallicence Ishiguro Yasunao Department of Surgery, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Sasanuma Hideki Department of Surgery, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Nitta Naotaka Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan aut Taniguchi Nobuyuki Department of Clinical Laboratory Medicine, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi, Japan aut Ogata Yukiyo Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi, Japan aut Yasuda Yoshikazu Department of Surgery, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Akiyama Iwaki Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan aut Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 47-50 1346-4523 42:1<47 2015 42 10396 https://doi.org/10.1007/s10396-014-0573-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-014-0573-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishiguro Yasunao Department of Surgery, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Sasanuma Hideki Department of Surgery, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Nitta Naotaka Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan aut NATIONALLICENCE 700 1- Taniguchi Nobuyuki Department of Clinical Laboratory Medicine, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ogata Yukiyo Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Yasuda Yoshikazu Department of Surgery, Jichi Medical University, School of Medicine, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Akiyama Iwaki Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 47-50 1346-4523 42:1<47 2015 42 10396