caa a22 4500 605539235 CHVBK 20210128100906.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10396-014-0558-4 doi (NATIONALLICENCE)springer-10.1007/s10396-014-0558-4 Combination of ultrasound and newly synthesized magnetic nanocapsules affects the temperature profile of CT26 tumors in BALB/c mice [Elektronische Daten] [Ali Shakeri-Zadeh, Samideh Khoei, Sepideh Khoee, Ali Sharifi, Mohammad-Bagher Shiran] Purpose: To investigate the effects of a combination of 3-MHz ultrasound waves with a new magnetic nanocapsule containing 5-fluorouracil (5-Fu) on the temperature profile of a mouse colon tumor (CT26) in BALB/c mice. Methods: Firstly, 5-Fu-loaded magnetic nanocapsules were synthesized using a multiple emulsion solvent evaporation procedure. Magnetic resonance imaging (MRI) was performed to evaluate the efficiency of nanocapsule localization in the tumor during magnetic drug targeting (MDT). Tumors were separately exposed to 3-MHz ultrasound waves at the intensities of 0.1, 0.3, 0.5, and 1W/cm2 for 10min in the absence and presence of nanocapsules. The temperature of the tumor was recorded at 1-min intervals. Results: The effective diameter of the nanocapsules was approximately 70nm, and it was demonstrated that magnetic nanoparticles were well dispersed inside the nanocapsules. MRI confirmed that the magnetic nanocapsules were successfully targeted to the tumor after accomplishing MDT. Temperature change due to sonication of the tumor was strongly intensity dependent. Moreover, temperature-time curves revealed that the magnetic nanocapsules significantly affected the temperature rise profile of a sonicated tumor. Conclusion: Data presented in this study would be helpful to develop an ultrasound-mediated MDT procedure so that temperature changes of the tumor and its surrounding normal tissues may be controllable. The Japan Society of Ultrasonics in Medicine, 2014 Cancer nationallicence Nanotechnology nationallicence Ultrasound nationallicence Thermal effects nationallicence Magnetic drug targeting nationallicence Shakeri-Zadeh Ali Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), PO Box 14155-5983, Tehran, Iran aut Khoei Samideh Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), PO Box 14155-5983, Tehran, Iran aut Khoee Sepideh Polymer Chemistry Department, School of Sciences, University of Tehran, Tehran, Iran aut Sharifi Ali Polymer Chemistry Department, School of Sciences, University of Tehran, Tehran, Iran aut Shiran Mohammad-Bagher Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), PO Box 14155-5983, Tehran, Iran aut Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 9-16 1346-4523 42:1<9 2015 42 10396 https://doi.org/10.1007/s10396-014-0558-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-014-0558-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shakeri-Zadeh Ali Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), PO Box 14155-5983, Tehran, Iran aut NATIONALLICENCE 700 1- Khoei Samideh Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), PO Box 14155-5983, Tehran, Iran aut NATIONALLICENCE 700 1- Khoee Sepideh Polymer Chemistry Department, School of Sciences, University of Tehran, Tehran, Iran aut NATIONALLICENCE 700 1- Sharifi Ali Polymer Chemistry Department, School of Sciences, University of Tehran, Tehran, Iran aut NATIONALLICENCE 700 1- Shiran Mohammad-Bagher Medical Physics Department, School of Medicine, Iran University of Medical Sciences (IUMS), PO Box 14155-5983, Tehran, Iran aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 9-16 1346-4523 42:1<9 2015 42 10396