caa a22 4500 605539278 CHVBK 20210128100906.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10396-014-0557-5 doi (NATIONALLICENCE)springer-10.1007/s10396-014-0557-5 Prenatal diagnosis of Klippel-Trenaunay-Weber syndrome with Kasabach-Merritt syndrome in utero [Elektronische Daten] [Kei Tanaka, Noriko Miyazaki, Miho Matsushima, Reiko Yagishita, Tomoko Izawa, Shinji Tanigaki, Keiji Sakai, Mitsutoshi Iwashita] Klippel-Trenaunay-Weber syndrome (KTWS), a congenital disease characterized by cutaneous hemangiomas, soft tissue and bone hypertrophy, and occasionally arteriovenous malformations, is extremely rare and its natural history in utero is unknown. We present a prenatally diagnosed case of KTWS complicated with Kasabach-Merritt syndrome in utero and fetal hydrops from acute anemia. The fetus was diagnosed with KTWS at 24weeks of gestation based on the ultrasound findings of hemangiomas and unilateral hypertrophy of the lower extremity. Acute enlargement of the hemangiomas and the appearance of new retroperitoneal hemangiomas were detected at 27weeks, along with skin edema and cardiomegaly. Doppler examination showed elevated peak systolic velocity in the middle cerebral artery, indicating acute fetal anemia. We believe the fetus's condition was complicated with Kasabach-Merritt syndrome in utero, which caused acute hemolytic anemia leading to high-output cardiac failure and fetal hydrops. The Japan Society of Ultrasonics in Medicine, 2014 Klippel-Trenaunay-Weber syndrome nationallicence Kasabach-Merritt syndrome nationallicence Ultrasound nationallicence Prenatal diagnosis nationallicence Fetal hydrops nationallicence Tanaka Kei Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Miyazaki Noriko Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Matsushima Miho Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Yagishita Reiko Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Izawa Tomoko Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Tanigaki Shinji Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Sakai Keiji Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Iwashita Mitsutoshi Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 109-112 1346-4523 42:1<109 2015 42 10396 https://doi.org/10.1007/s10396-014-0557-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-014-0557-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanaka Kei Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Miyazaki Noriko Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Matsushima Miho Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Yagishita Reiko Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Izawa Tomoko Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Tanigaki Shinji Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Sakai Keiji Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwashita Mitsutoshi Department of Obstetrics and Gynecology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181-8611, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 109-112 1346-4523 42:1<109 2015 42 10396