caa a22 4500 605539383 CHVBK 20210128100906.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s10396-014-0565-5 doi (NATIONALLICENCE)springer-10.1007/s10396-014-0565-5 Microscopic observation of glass bead movement in soft tissue-mimicking phantom under ultrasound PW mode scanning [Elektronische Daten] [Lei Liu, Kenichi Funamoto, Masayuki Tanabe, Toshiyuki Hayase] Previous studies have demonstrated that stones and calcification in soft tissue show special enhancement in response to color flow (CF) or pulse Doppler (PW) mode ultrasound scan. This phenomenon is known as the "twinkling sign (TS)”. The authors conducted an in vitro experiment to investigate the mechanism of TS occurrence by observing a glass bead in a transparent PVA-H soft tissue-mimicking phantom. The TS in PW mode showed a low-power and slow-velocity spectrum. At the same time, analysis of images by high-speed camera showed that the glass bead in the phantom oscillated following the pulse repetition frequency (PRF) of the PW mode ultrasound scan. The harmonic oscillations were confirmed, as well. The ultrasound radiation force-driven micro-oscillation possibly affects the ultrasound propagation around the scatterer and triggers random signals in the received echo signals. The results indicate that TS is a phenomenon based on complicated acoustic-mechanical interaction of multiple mechanisms. Further investigation is required for gaining a full understanding of the mechanism of TS occurrence and its clinical application. The Japan Society of Ultrasonics in Medicine, 2014 Twinkling sign nationallicence Micro-calcification nationallicence Tissue-mimicking phantom nationallicence Poly (vinyl alcohol) hydro gel nationallicence PW scan nationallicence Liu Lei GE Healthcare Japan Corporation, Tokyo, Japan aut Funamoto Kenichi Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba-ku, 980-8577, Sendai, Japan aut Tanabe Masayuki Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan aut Hayase Toshiyuki Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba-ku, 980-8577, Sendai, Japan aut Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 59-63 1346-4523 42:1<59 2015 42 10396 https://doi.org/10.1007/s10396-014-0565-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 brief-communication jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-014-0565-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Lei GE Healthcare Japan Corporation, Tokyo, Japan aut NATIONALLICENCE 700 1- Funamoto Kenichi Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba-ku, 980-8577, Sendai, Japan aut NATIONALLICENCE 700 1- Tanabe Masayuki Graduate School of Science and Technology, Kumamoto University, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hayase Toshiyuki Institute of Fluid Science, Tohoku University, 2-1-1 Katahira, Aoba-ku, 980-8577, Sendai, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/1(2015-01-01), 59-63 1346-4523 42:1<59 2015 42 10396