caa a22 4500 605539618 CHVBK 20210128100907.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s10396-014-0603-3 doi (NATIONALLICENCE)springer-10.1007/s10396-014-0603-3 Value of shear wave elastography for predicting hepatocellular carcinoma and esophagogastric varices in patients with chronic liver disease [Elektronische Daten] [Yoshitaka Kasai, Fuminori Moriyasu, Kazuhiro Saito, Takeshi Hara, Yoshiyuki Kobayashi, Ikuo Nakamura, Katsutoshi Sugimoto] Purpose: To assess the value of shear wave elastography (SWE) for predicting the presence of hepatocellular carcinoma (HCC) and esophagogastric varices (EGV) in patients with chronic liver disease. Methods: Liver tissue stiffness, as well as various other parameters potentially associated with HCC and portal hypertension, was measured by SWE in 273 patients with chronic liver disease. Among these patients, HCC was present in 89 and absent in 184, and EGV were present in 16 and absent in 257. The diagnostic performance of liver tissue stiffness and other clinical parameters in predicting the presence of HCC and EGV was evaluated using receiver operating characteristic (ROC) curves and the area under the ROC curve (AUROC). Results: With regard to HCC, liver tissue stiffness was significantly higher in patients with HCC (18.65±10.78kPa) than in those without HCC (10.64±8.04kPa; P<0.0001). Significant differences in patient age (P<0.0001), albumin (P<0.0001), platelet count (P<0.0001), AFP (P<0.0001), and DCP (P<0.0001) were also observed between patients with and without HCC. Liver tissue stiffness showed the largest AUROC (0.791). With regard to EGV, liver tissue stiffness was significantly higher in patients with EGV (22.65±10.19kPa) than in those without EGV (12.67±9.45kPa; P<0.0001). Significant differences in albumin (P<0.0001) and platelet count (P<0.0001) were also observed between patients with and without EGV. Conclusions: Liver tissue stiffness measured by SWE is an independent factor for predicting the presence of HCC and EGV in patients with chronic liver disease. The Japan Society of Ultrasonics in Medicine, 2015 Shear wave elastography nationallicence Hepatocellular carcinoma nationallicence Esophagogastric varices nationallicence Ultrasound nationallicence Chronic liver disease nationallicence Kasai Yoshitaka Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut Moriyasu Fuminori Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut Saito Kazuhiro Department of Radiology, Tokyo Medical University, Tokyo, Japan aut Hara Takeshi Department of Intelligent Image Information, Gifu University Graduate School of Medicine, Gifu, Japan aut Kobayashi Yoshiyuki Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut Nakamura Ikuo Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut Sugimoto Katsutoshi Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut Journal of Medical Ultrasonics Springer Japan 42/3(2015-07-01), 349-355 1346-4523 42:3<349 2015 42 10396 https://doi.org/10.1007/s10396-014-0603-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-014-0603-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kasai Yoshitaka Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Moriyasu Fuminori Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Kazuhiro Department of Radiology, Tokyo Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Hara Takeshi Department of Intelligent Image Information, Gifu University Graduate School of Medicine, Gifu, Japan aut NATIONALLICENCE 700 1- Kobayashi Yoshiyuki Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Ikuo Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugimoto Katsutoshi Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, 160-0023, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/3(2015-07-01), 349-355 1346-4523 42:3<349 2015 42 10396