caa a22 4500 605539774 CHVBK 20210128100908.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10396-015-0643-3 doi (NATIONALLICENCE)springer-10.1007/s10396-015-0643-3 Modeling the thermo-acoustic effects of thermal-dependent speed of sound and acoustic absorption of biological tissues during focused ultrasound hyperthermia [Elektronische Daten] [S. López-Haro, M. Gutiérrez, A. Vera, L. Leija] Purpose: To evaluate the effects of thermal dependence of speed of sound (SOS) and acoustic absorption of biological tissues during noninvasive focused ultrasound (US) hyperthermia therapy. Methods: A finite element (FE) model was used to simulate hyperthermia therapy in the liver by noninvasive focused US. The model consisted of an ultrasonic focused transducer radiating a four-layer biological medium composed of skin, fat, muscle, and liver. The acoustic field and temperature distribution along the layers were obtained after 15s of hyperthermia therapy using the bio-heat equation. The model solution was found with and without the thermal dependence of SOS and acoustic absorption of biological tissues. Results: The inclusion of the thermal dependence of the SOS generated an increment of 0.4mm in the longitudinal focus axis of the acoustic field. Moreover, results indicate an increment of the hyperthermia area (zone with temperature above 43°C), and a maximum temperature difference of almost 3.5°C when the thermal dependence of absorption was taken into account. Conclusion: The increment of the achieved temperatures at the treatment zone indicated that the effects produced by the thermal dependence of SOS and absorption must be accounted for when planning hyperthermia treatment in order to avoid overheating undesired regions. The Japan Society of Ultrasonics in Medicine, 2015 Absorption nationallicence Speed of sound nationallicence Temperature dependence nationallicence Finite element nationallicence Hyperthermia nationallicence Ultrasound nationallicence López-Haro S. Electrical Engineering Department, Bioelectronics Section, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, Del. Gustavo A. Madero, 07360, Mexico City, Mexico aut Gutiérrez M. Instituto Nacional de Rehabilitación, CONACyT, Subdirección de Investigación Tecnológica, Calz. México Xochimilco No. 289, Col. Arenal de Guadalupe, Del. Xochimilco, 14389, Mexico City, Mexico aut Vera A. Electrical Engineering Department, Bioelectronics Section, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, Del. Gustavo A. Madero, 07360, Mexico City, Mexico aut Leija L. Electrical Engineering Department, Bioelectronics Section, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, Del. Gustavo A. Madero, 07360, Mexico City, Mexico aut Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 489-498 1346-4523 42:4<489 2015 42 10396 https://doi.org/10.1007/s10396-015-0643-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-015-0643-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- López-Haro S. Electrical Engineering Department, Bioelectronics Section, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, Del. Gustavo A. Madero, 07360, Mexico City, Mexico aut NATIONALLICENCE 700 1- Gutiérrez M. Instituto Nacional de Rehabilitación, CONACyT, Subdirección de Investigación Tecnológica, Calz. México Xochimilco No. 289, Col. Arenal de Guadalupe, Del. Xochimilco, 14389, Mexico City, Mexico aut NATIONALLICENCE 700 1- Vera A. Electrical Engineering Department, Bioelectronics Section, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, Del. Gustavo A. Madero, 07360, Mexico City, Mexico aut NATIONALLICENCE 700 1- Leija L. Electrical Engineering Department, Bioelectronics Section, Centro de Investigación y de Estudios Avanzados del IPN, Cinvestav-IPN, Av. IPN 2508, Col. San Pedro Zacatenco, Del. Gustavo A. Madero, 07360, Mexico City, Mexico aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 489-498 1346-4523 42:4<489 2015 42 10396