New approach for local cancer treatment using pulsed high-intensity focused ultrasound and phase-change nanodroplets
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| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s10396-015-0634-4 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s10396-015-0634-4 | ||
| 245 | 0 | 0 | |a New approach for local cancer treatment using pulsed high-intensity focused ultrasound and phase-change nanodroplets |h [Elektronische Daten] |c [Reiko Ashida, Ken-ichi Kawabata, Takashi Maruoka, Rei Asami, Hideki Yoshikawa, Rena Takakura, Tatsuya Ioka, Kazuhiro Katayama, Sachiko Tanaka] |
| 520 | 3 | |a Purpose: The aim of this study was to investigate the combination effects of pulsed HIFU (pHIFU) and phase-change nanodroplets (PCND) as a sensitizer on efficient induction of mechanical effects of pHIFU and chemically enhanced tumor growth inhibition for local anti-tumor therapy. Method: Changes in growth of colon 26 tumor tissue inoculated onto CDF1 mice were evaluated by the following treatments. (1) pHIFU exposure (1.1MHz, 3.2kW/cm2, 300cycles, and 50ms interval) for 60s, (2) PCND (1%) injection, (3) adriamycin (4mg/kg) injection, (4) pHIFU exposure after PCND injection, and (5) pHIFU exposure after PCND+adriamycin injection simultaneously. Results: Significant changes in tumor growth were observed in the group with combination of pHIFU and PCND, although single therapy did not show any significant difference. PCND enhanced mechanical tissue fractionation by pHIFU, which was detectable by Real-time tissue elastography. Moreover, the combination of pHIFU and PCND+Adriamycin suppressed the tumor growth for 2weeks, and 3 of 4 mice did not show any sign of regrowth during the 30-day observation. Conclusion: The combination of pHIFU and PCND exerted a significant anti-tumor effect and may be a new candidate for treatment of locally advanced cancer. | |
| 540 | |a The Japan Society of Ultrasonics in Medicine, 2015 | ||
| 690 | 7 | |a HIFU |2 nationallicence | |
| 690 | 7 | |a Drug delivery system |2 nationallicence | |
| 690 | 7 | |a Superheated perfluorocarbon droplet |2 nationallicence | |
| 690 | 7 | |a Histotripsy |2 nationallicence | |
| 690 | 7 | |a Mechanical effect |2 nationallicence | |
| 690 | 7 | |a Cancer |2 nationallicence | |
| 700 | 1 | |a Ashida |D Reiko |u Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Kawabata |D Ken-ichi |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Maruoka |D Takashi |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Asami |D Rei |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Yoshikawa |D Hideki |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | |
| 700 | 1 | |a Takakura |D Rena |u Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan |4 aut | |
| 700 | 1 | |a Ioka |D Tatsuya |u Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Katayama |D Kazuhiro |u Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | |
| 700 | 1 | |a Tanaka |D Sachiko |u Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan |4 aut | |
| 773 | 0 | |t Journal of Medical Ultrasonics |d Springer Japan |g 42/4(2015-10-01), 457-466 |x 1346-4523 |q 42:4<457 |1 2015 |2 42 |o 10396 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10396-015-0634-4 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a research-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10396-015-0634-4 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ashida |D Reiko |u Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kawabata |D Ken-ichi |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Maruoka |D Takashi |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Asami |D Rei |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yoshikawa |D Hideki |u Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Takakura |D Rena |u Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ioka |D Tatsuya |u Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Katayama |D Kazuhiro |u Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Tanaka |D Sachiko |u Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Medical Ultrasonics |d Springer Japan |g 42/4(2015-10-01), 457-466 |x 1346-4523 |q 42:4<457 |1 2015 |2 42 |o 10396 | ||