caa a22 4500 605539847 CHVBK 20210128100908.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10396-015-0634-4 doi (NATIONALLICENCE)springer-10.1007/s10396-015-0634-4 New approach for local cancer treatment using pulsed high-intensity focused ultrasound and phase-change nanodroplets [Elektronische Daten] [Reiko Ashida, Ken-ichi Kawabata, Takashi Maruoka, Rei Asami, Hideki Yoshikawa, Rena Takakura, Tatsuya Ioka, Kazuhiro Katayama, Sachiko Tanaka] Purpose: The aim of this study was to investigate the combination effects of pulsed HIFU (pHIFU) and phase-change nanodroplets (PCND) as a sensitizer on efficient induction of mechanical effects of pHIFU and chemically enhanced tumor growth inhibition for local anti-tumor therapy. Method: Changes in growth of colon 26 tumor tissue inoculated onto CDF1 mice were evaluated by the following treatments. (1) pHIFU exposure (1.1MHz, 3.2kW/cm2, 300cycles, and 50ms interval) for 60s, (2) PCND (1%) injection, (3) adriamycin (4mg/kg) injection, (4) pHIFU exposure after PCND injection, and (5) pHIFU exposure after PCND+adriamycin injection simultaneously. Results: Significant changes in tumor growth were observed in the group with combination of pHIFU and PCND, although single therapy did not show any significant difference. PCND enhanced mechanical tissue fractionation by pHIFU, which was detectable by Real-time tissue elastography. Moreover, the combination of pHIFU and PCND+Adriamycin suppressed the tumor growth for 2weeks, and 3 of 4 mice did not show any sign of regrowth during the 30-day observation. Conclusion: The combination of pHIFU and PCND exerted a significant anti-tumor effect and may be a new candidate for treatment of locally advanced cancer. The Japan Society of Ultrasonics in Medicine, 2015 HIFU nationallicence Drug delivery system nationallicence Superheated perfluorocarbon droplet nationallicence Histotripsy nationallicence Mechanical effect nationallicence Cancer nationallicence Ashida Reiko Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Kawabata Ken-ichi Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut Maruoka Takashi Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut Asami Rei Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut Yoshikawa Hideki Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut Takakura Rena Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan aut Ioka Tatsuya Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Katayama Kazuhiro Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Tanaka Sachiko Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan aut Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 457-466 1346-4523 42:4<457 2015 42 10396 https://doi.org/10.1007/s10396-015-0634-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-015-0634-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ashida Reiko Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Kawabata Ken-ichi Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut NATIONALLICENCE 700 1- Maruoka Takashi Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut NATIONALLICENCE 700 1- Asami Rei Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshikawa Hideki Research & Development Group, Hitachi, Ltd., 1-280 Higashi Koigakubo, 180-8601, Kokubunji, Tokyo, Japan aut NATIONALLICENCE 700 1- Takakura Rena Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan aut NATIONALLICENCE 700 1- Ioka Tatsuya Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Katayama Kazuhiro Department of Cancer Survey and Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Tanaka Sachiko Department of Cancer Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 457-466 1346-4523 42:4<457 2015 42 10396