caa a22 4500 605539863 CHVBK 20210128100909.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10396-015-0645-1 doi (NATIONALLICENCE)springer-10.1007/s10396-015-0645-1 A case of fetal osteogenesis imperfecta type 2A: longitudinal observation of natural course in utero and pitfalls for prenatal ultrasound diagnosis [Elektronische Daten] [Ibuki Kimura, Ryota Araki, Toshiyuki Yoshizato, Shingo Miyamoto] We present a case of osteogenesis imperfecta (OI) type 2A in which a natural course in utero was observed from 23weeks' gestation to term. At 23weeks' gestation, a sonographic examination showed a cloverleaf skull-like head, a narrow thorax, and marked shortening of the long bones with bowing of the femurs and humeri. Follow-up examinations showed that the cloverleaf skull-like head was not evident at 28weeks' gestation. Discontinuity of the ribs and femurs was observed at 26 and 30weeks' gestation, respectively. This finding suggested bone fractures, which were confirmed by three-dimensional computed tomography at 32weeks' gestation. Ultrasonographic findings of bones, including the long bones and calvarium, changed with advancing gestation during the second trimester. Characteristic features of OI type 2A were evident during the late second to early third trimesters. Repeated ultrasonographic examinations together with three-dimensional computed tomography are necessary for the definitive diagnosis of OI type 2A in the second trimester. The Japan Society of Ultrasonics in Medicine, 2015 Osteogenesis imperfecta type 2A nationallicence Ultrasonography nationallicence Prenatal diagnosis nationallicence Kimura Ibuki Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Araki Ryota Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Yoshizato Toshiyuki Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut Miyamoto Shingo Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 565-570 1346-4523 42:4<565 2015 42 10396 https://doi.org/10.1007/s10396-015-0645-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-015-0645-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kimura Ibuki Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Araki Ryota Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yoshizato Toshiyuki Center for Maternal, Fetal and Neonatal Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Miyamoto Shingo Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 565-570 1346-4523 42:4<565 2015 42 10396