caa a22 4500 60553991X CHVBK 20210128100909.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10396-015-0627-3 doi (NATIONALLICENCE)springer-10.1007/s10396-015-0627-3 Quantitative sonographic image analysis for hepatic nodules: a pilot study [Elektronische Daten] [Naoki Matsumoto, Masahiro Ogawa, Kentaro Takayasu, Midori Hirayama, Takao Miura, Katsuhiko Shiozawa, Masahisa Abe, Hiroshi Nakagawara, Mitsuhiko Moriyama, Seiichi Udagawa] Purpose: The aim of this study was to investigate the feasibility of quantitative image analysis to differentiate hepatic nodules on gray-scale sonographic images. Methods: We retrospectively evaluated 35 nodules from 31 patients with hepatocellular carcinoma (HCC), 60 nodules from 58 patients with liver hemangioma, and 22 nodules from 22 patients with liver metastasis. Gray-scale sonographic images were evaluated with subjective judgment and image analysis using ImageJ software. Reviewers classified the shape of nodules as irregular or round, and the surface of nodules as rough or smooth. Results: Circularity values were lower in the irregular group than in the round group (median 0.823, 0.892; range 0.641-0.915, 0.784-0.932, respectively; P=3.21×10−10). Solidity values were lower in the rough group than in the smooth group (median 0.957, 0.968; range 0.894-0.986, 0.933-0.988, respectively; P=1.53×10−4). The HCC group had higher circularity and solidity values than the hemangioma group. The HCC and liver metastasis groups had lower median, mean, modal, and minimum gray values than the hemangioma group. Multivariate analysis showed circularity [standardized odds ratio (OR), 2.077; 95% confidential interval (CI)=1.295-3.331; P=0.002] and minimum gray value (OR 0.482; 95% CI=0.956-0.990; P=0.001) as factors predictive of malignancy. The combination of subjective judgment and image analysis provided 58.3% sensitivity and 89.5% specificity with AUC=0.739, representing an improvement over subjective judgment alone (68.4% sensitivity, 75.0% specificity, AUC=0.701) (P=0.008). Conclusion: Quantitative image analysis for ultrasonic images of hepatic nodules may correlate with subjective judgment in predicting malignancy. The Japan Society of Ultrasonics in Medicine, 2015 Quantitative image analysis nationallicence Ultrasonography nationallicence Hepatocellular carcinoma nationallicence Liver hemangioma nationallicence Liver metastasis nationallicence Matsumoto Naoki Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Ogawa Masahiro Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Takayasu Kentaro Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Hirayama Midori Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Miura Takao Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Shiozawa Katsuhiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Abe Masahisa Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Nakagawara Hiroshi Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Moriyama Mitsuhiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Udagawa Seiichi Department of Mathematics, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 505-512 1346-4523 42:4<505 2015 42 10396 https://doi.org/10.1007/s10396-015-0627-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-015-0627-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsumoto Naoki Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogawa Masahiro Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Takayasu Kentaro Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Hirayama Midori Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Miura Takao Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Shiozawa Katsuhiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Abe Masahisa Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakagawara Hiroshi Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Moriyama Mitsuhiko Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 700 1- Udagawa Seiichi Department of Mathematics, Nihon University School of Medicine, 30-1 Oyaguchi Kamimachi, Itabashi, 173-8610, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/4(2015-10-01), 505-512 1346-4523 42:4<505 2015 42 10396