Evolution of pancreas in aging: degenerative variation or early changes of disease?
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| 024 | 7 | 0 | |a 10.1007/s10396-014-0576-2 |2 doi |
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| 245 | 0 | 0 | |a Evolution of pancreas in aging: degenerative variation or early changes of disease? |h [Elektronische Daten] |c [Tanyaporn Chantarojanasiri, Yoshiki Hirooka, Thawee Ratanachu-ek, Hiroki Kawashima, Eizaburo Ohno, Hidemi Goto] |
| 520 | 3 | |a Pancreatic changes in aging have been described for many decades. They involve not only pancreatic parenchyma but also pancreatic ductal, microscopic, and exocrine functional changes. There have been many studies of these changes based on pathology and various imaging modalities, as well as functional studies. The pancreatic volume was found to decrease with advancing age, with a higher incidence of pancreatic steatosis, as demonstrated in autopsy and imaging studies. The pancreatic ductal structure has been described with wide ranges of normal variation, but many studies have shown a tendency toward enlargement with advancing age. By endoscopic ultrasound imaging, the aging pancreas may exhibit abnormal findings similar to chronic pancreatitis. Microscopically, there has been evidence of patchy lobular fibrosis and papillary hyperplasia and demonstrable k-ras mutation in both normal and dysplastic ductal mucosa. The evidence of pancreatic exocrine insufficiency has yielded conflicting results, but most studies have shown a tendency toward decreased pancreatic exocrine function in the elderly. Differentiating pancreatic change in the elderly from early chronic pancreatitis may be difficult as there are limited studies to compare these two conditions in terms of structural and functional changes. | |
| 540 | |a The Japan Society of Ultrasonics in Medicine, 2014 | ||
| 690 | 7 | |a Pancreas |2 nationallicence | |
| 690 | 7 | |a Age-related change |2 nationallicence | |
| 700 | 1 | |a Chantarojanasiri |D Tanyaporn |u Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan |4 aut | |
| 700 | 1 | |a Hirooka |D Yoshiki |u Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan |4 aut | |
| 700 | 1 | |a Ratanachu-ek |D Thawee |u Department of Surgery, Rajavithi Hospital, Bangkok, Thailand |4 aut | |
| 700 | 1 | |a Kawashima |D Hiroki |u Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan |4 aut | |
| 700 | 1 | |a Ohno |D Eizaburo |u Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan |4 aut | |
| 700 | 1 | |a Goto |D Hidemi |u Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan |4 aut | |
| 773 | 0 | |t Journal of Medical Ultrasonics |d Springer Japan |g 42/2(2015-04-01), 177-183 |x 1346-4523 |q 42:2<177 |1 2015 |2 42 |o 10396 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10396-014-0576-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s10396-014-0576-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Chantarojanasiri |D Tanyaporn |u Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Hirooka |D Yoshiki |u Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ratanachu-ek |D Thawee |u Department of Surgery, Rajavithi Hospital, Bangkok, Thailand |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kawashima |D Hiroki |u Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ohno |D Eizaburo |u Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Goto |D Hidemi |u Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Medical Ultrasonics |d Springer Japan |g 42/2(2015-04-01), 177-183 |x 1346-4523 |q 42:2<177 |1 2015 |2 42 |o 10396 | ||