caa a22 4500 605540047 CHVBK 20210128100910.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10396-014-0576-2 doi (NATIONALLICENCE)springer-10.1007/s10396-014-0576-2 Evolution of pancreas in aging: degenerative variation or early changes of disease? [Elektronische Daten] [Tanyaporn Chantarojanasiri, Yoshiki Hirooka, Thawee Ratanachu-ek, Hiroki Kawashima, Eizaburo Ohno, Hidemi Goto] Pancreatic changes in aging have been described for many decades. They involve not only pancreatic parenchyma but also pancreatic ductal, microscopic, and exocrine functional changes. There have been many studies of these changes based on pathology and various imaging modalities, as well as functional studies. The pancreatic volume was found to decrease with advancing age, with a higher incidence of pancreatic steatosis, as demonstrated in autopsy and imaging studies. The pancreatic ductal structure has been described with wide ranges of normal variation, but many studies have shown a tendency toward enlargement with advancing age. By endoscopic ultrasound imaging, the aging pancreas may exhibit abnormal findings similar to chronic pancreatitis. Microscopically, there has been evidence of patchy lobular fibrosis and papillary hyperplasia and demonstrable k-ras mutation in both normal and dysplastic ductal mucosa. The evidence of pancreatic exocrine insufficiency has yielded conflicting results, but most studies have shown a tendency toward decreased pancreatic exocrine function in the elderly. Differentiating pancreatic change in the elderly from early chronic pancreatitis may be difficult as there are limited studies to compare these two conditions in terms of structural and functional changes. The Japan Society of Ultrasonics in Medicine, 2014 Pancreas nationallicence Age-related change nationallicence Chantarojanasiri Tanyaporn Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Hirooka Yoshiki Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan aut Ratanachu-ek Thawee Department of Surgery, Rajavithi Hospital, Bangkok, Thailand aut Kawashima Hiroki Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Ohno Eizaburo Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan aut Goto Hidemi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Journal of Medical Ultrasonics Springer Japan 42/2(2015-04-01), 177-183 1346-4523 42:2<177 2015 42 10396 https://doi.org/10.1007/s10396-014-0576-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10396-014-0576-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chantarojanasiri Tanyaporn Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Hirooka Yoshiki Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan aut NATIONALLICENCE 700 1- Ratanachu-ek Thawee Department of Surgery, Rajavithi Hospital, Bangkok, Thailand aut NATIONALLICENCE 700 1- Kawashima Hiroki Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Ohno Eizaburo Department of Endoscopy, Nagoya University Hospital, 65 Tsuruma-cho, Showa-ku, 466-8550, Nagoya City, Japan aut NATIONALLICENCE 700 1- Goto Hidemi Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 773 0- Journal of Medical Ultrasonics Springer Japan 42/2(2015-04-01), 177-183 1346-4523 42:2<177 2015 42 10396