caa a22 4500 605542880 CHVBK 20210128100923.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00109-014-1231-5 doi (NATIONALLICENCE)springer-10.1007/s00109-014-1231-5 Vestweber Dietmar Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149, Münster, Germany aut Cadherins in tissue architecture and disease [Elektronische Daten] [Dietmar Vestweber] Cadherins are homophilic cell adhesion molecules that determine tissue architecture and control cell contact formation and dissociation in development and tissue homeostasis of all metazoans. These adhesion molecules mediate homophilic interactions between cells and are linked inside the cell via a complex set of cytosolic factors to the actin cytoskeleton. These interactions are key to the plasticity of intercellular junctions and to the various signaling functions of the cadherins. This forms the basis for cadherin-driven cell behavior, cell differentiation, and regeneration of tissue structures. Consequently, mutations in cadherins are the cause of various human pathologies, with cancer representing one of the most prominent examples. Springer-Verlag Berlin Heidelberg, 2014 Cell adhesion nationallicence Cadherins nationallicence Catenins nationallicence Junctions nationallicence Mechanotransduction nationallicence Cancer nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/1(2015-01-01), 5-11 0946-2716 93:1<5 2015 93 109 https://doi.org/10.1007/s00109-014-1231-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-014-1231-5 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Vestweber Dietmar Max Planck Institute for Molecular Biomedicine, Röntgenstr. 20, 48149, Münster, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/1(2015-01-01), 5-11 0946-2716 93:1<5 2015 93 109