Targeting autophagy in skin diseases
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| 024 | 7 | 0 | |a 10.1007/s00109-014-1225-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00109-014-1225-3 | ||
| 245 | 0 | 0 | |a Targeting autophagy in skin diseases |h [Elektronische Daten] |c [Teng Yu, Joshua Zuber, Jinchao Li] |
| 520 | 3 | |a Autophagy is a major intracellular degradative process by which cytoplasmic materials are sequestered in double-membraned vesicles and degraded upon fusion with lysosomes. Under normal circumstances, basal autophagy is necessary to maintain cellular homeostasis by scavenging dysfunctional or damaged organelles or proteins. In addition to its vital homeostatic role, this degradation pathway has been implicated in many different cellular processes such as cell apoptosis, inflammation, pathogen clearance, and antigen presentation and thereby has been linked to a variety of human disorders, including metabolic conditions, neurodegenerative diseases, cancers, and infectious diseases. The skin, the largest organ of the body, serves as the first line of defense against many different environmental insults; however, only a few studies have examined the effect of autophagy on the pathogenesis of skin diseases. This review provides an overview of the mechanisms of autophagy and highlights recent findings relevant to the role of autophagy in skin diseases and strategies for therapeutic modulation. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2014 | ||
| 690 | 7 | |a Autophagy |2 nationallicence | |
| 690 | 7 | |a Psoriasis |2 nationallicence | |
| 690 | 7 | |a Systemic lupus erythematosus |2 nationallicence | |
| 690 | 7 | |a Vitiligo |2 nationallicence | |
| 690 | 7 | |a Infectious skin diseases |2 nationallicence | |
| 690 | 7 | |a Cancer |2 nationallicence | |
| 700 | 1 | |a Yu |D Teng |u Department of Dermatology, Shandong Jining No.1 People's Hospital, 272111, Jining, Shandong, China |4 aut | |
| 700 | 1 | |a Zuber |D Joshua |u Department of Biochemistry and Molecular Biology, College of Natural Sciences, University of Massachusetts, 01003, Amherst, MA, USA |4 aut | |
| 700 | 1 | |a Li |D Jinchao |u Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, 100 Holdsworth Way, 01003, Amherst, MA, USA |4 aut | |
| 773 | 0 | |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/1(2015-01-01), 31-38 |x 0946-2716 |q 93:1<31 |1 2015 |2 93 |o 109 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-014-1225-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00109-014-1225-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Yu |D Teng |u Department of Dermatology, Shandong Jining No.1 People's Hospital, 272111, Jining, Shandong, China |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Zuber |D Joshua |u Department of Biochemistry and Molecular Biology, College of Natural Sciences, University of Massachusetts, 01003, Amherst, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Li |D Jinchao |u Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, 100 Holdsworth Way, 01003, Amherst, MA, USA |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/1(2015-01-01), 31-38 |x 0946-2716 |q 93:1<31 |1 2015 |2 93 |o 109 | ||