caa a22 4500 605542902 CHVBK 20210128100923.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00109-014-1225-3 doi (NATIONALLICENCE)springer-10.1007/s00109-014-1225-3 Targeting autophagy in skin diseases [Elektronische Daten] [Teng Yu, Joshua Zuber, Jinchao Li] Autophagy is a major intracellular degradative process by which cytoplasmic materials are sequestered in double-membraned vesicles and degraded upon fusion with lysosomes. Under normal circumstances, basal autophagy is necessary to maintain cellular homeostasis by scavenging dysfunctional or damaged organelles or proteins. In addition to its vital homeostatic role, this degradation pathway has been implicated in many different cellular processes such as cell apoptosis, inflammation, pathogen clearance, and antigen presentation and thereby has been linked to a variety of human disorders, including metabolic conditions, neurodegenerative diseases, cancers, and infectious diseases. The skin, the largest organ of the body, serves as the first line of defense against many different environmental insults; however, only a few studies have examined the effect of autophagy on the pathogenesis of skin diseases. This review provides an overview of the mechanisms of autophagy and highlights recent findings relevant to the role of autophagy in skin diseases and strategies for therapeutic modulation. Springer-Verlag Berlin Heidelberg, 2014 Autophagy nationallicence Psoriasis nationallicence Systemic lupus erythematosus nationallicence Vitiligo nationallicence Infectious skin diseases nationallicence Cancer nationallicence Yu Teng Department of Dermatology, Shandong Jining No.1 People's Hospital, 272111, Jining, Shandong, China aut Zuber Joshua Department of Biochemistry and Molecular Biology, College of Natural Sciences, University of Massachusetts, 01003, Amherst, MA, USA aut Li Jinchao Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, 100 Holdsworth Way, 01003, Amherst, MA, USA aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/1(2015-01-01), 31-38 0946-2716 93:1<31 2015 93 109 https://doi.org/10.1007/s00109-014-1225-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-014-1225-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Teng Department of Dermatology, Shandong Jining No.1 People's Hospital, 272111, Jining, Shandong, China aut NATIONALLICENCE 700 1- Zuber Joshua Department of Biochemistry and Molecular Biology, College of Natural Sciences, University of Massachusetts, 01003, Amherst, MA, USA aut NATIONALLICENCE 700 1- Li Jinchao Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts, 100 Holdsworth Way, 01003, Amherst, MA, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/1(2015-01-01), 31-38 0946-2716 93:1<31 2015 93 109