caa a22 4500 605543011 CHVBK 20210128100924.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00109-015-1305-z doi (NATIONALLICENCE)springer-10.1007/s00109-015-1305-z G-protein-mediated signaling in vascular smooth muscle cells—implications for vascular disease [Elektronische Daten] [Till Althoff, Stefan Offermanns] Differentiated vascular smooth muscle cells (VSMCs) are critical determinants of vascular tone and blood pressure. However, during vascular remodeling processes, which occur in response to changing hemodynamics or vascular injury, VSMCs lose most of their contractile functions in a dedifferentiation process, which goes along with cell proliferation and cell migration. VSMCs are under the constant control of a variety of mediators with vasocontractile or vasodilatory properties. Most of these mediators act through G-protein-coupled receptors, which, via different downstream signaling pathways, regulate the phosphorylation of myosin light chain and thereby control vascular tone. Recent work indicates that procontractile G-protein-mediated signal transduction pathways are also critical regulators of vascular smooth muscle dedifferentiation and redifferentiation. This review describes some of the key G-protein-mediated signal transduction pathways regulating vascular tone and VSMC differentiation and their involvement in cardiovascular diseases. Springer-Verlag Berlin Heidelberg, 2015 Vascular smooth muscle cells nationallicence G-protein-coupled receptors nationallicence G-protein signaling nationallicence Althoff Till Department of Cardiology & Vascular Medicine and Center for Cardiovascular Research (CCR), Charité Campus Mitte, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany aut Offermanns Stefan Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Ludwigstr 43, 61231, Bad Nauheim, Germany aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/9(2015-09-01), 973-981 0946-2716 93:9<973 2015 93 109 https://doi.org/10.1007/s00109-015-1305-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1305-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Althoff Till Department of Cardiology & Vascular Medicine and Center for Cardiovascular Research (CCR), Charité Campus Mitte, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany aut NATIONALLICENCE 700 1- Offermanns Stefan Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Ludwigstr 43, 61231, Bad Nauheim, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/9(2015-09-01), 973-981 0946-2716 93:9<973 2015 93 109