caa a22 4500 605543062 CHVBK 20210128100924.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00109-015-1323-x doi (NATIONALLICENCE)springer-10.1007/s00109-015-1323-x Lohse Martin Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany aut The ins and outs of adrenergic signaling [Elektronische Daten] [Martin Lohse] Adrenergic signaling, in particular signaling in the sympathetic nervous system, is a prime example of the control of an essential physiological system. It has served as a model system both for the control of mediator release and for receptor signaling and regulation. This review covers the historical development of the field and then addresses issues that represent key fields of ongoing research: the mechanisms and kinetics of receptor activation, temporal patterns of downstream signaling and signal bias, receptor mobility and aggregation, and signal compartmentation and specificity. The available evidence suggests that adrenergic signaling may involve complex spatiotemporal patterns, which give texture to the signaling process and may contain additional biological information. Springer-Verlag Berlin Heidelberg, 2015 G-protein-coupled receptors nationallicence Receptor activation nationallicence Receptor kinetics nationallicence Compartmentation nationallicence cAMP nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/9(2015-09-01), 955-962 0946-2716 93:9<955 2015 93 109 https://doi.org/10.1007/s00109-015-1323-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1323-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lohse Martin Institute of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/9(2015-09-01), 955-962 0946-2716 93:9<955 2015 93 109