caa a22 4500 605543100 CHVBK 20210128100924.0 cr unu---uuuuu 210128e20150901xx s 000 0 eng 10.1007/s00109-015-1298-7 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1298-7 TRPC3‐dependent synaptic transmission in central mammalian neurons [Elektronische Daten] [Jana Hartmann, Arthur Konnerth] The transient receptor potential (TRPC) proteins form non-selective cation channels that are activated downstream of Gq-phospholipase C-coupled receptors. TRPC3, one of the seven members of the TRPC subfamily, combines functions of an unspecific ion channel and a signal transducer. In the mammalian brain, the expression of TRPC3 is highest in cerebellar Purkinje cells, the principal neurons, and the sole output of the cerebellar cortex. In this review, we summarize findings identifying TRPC3 channels as integral components of glutamatergic metabotropic synaptic transmission. We give an overview of postsynaptic interaction partners and activation mechanisms of TRPC3 in central neurons. Finally, we address the deleterious consequences of distorted TRPC3 synaptic signaling for cerebellar function in different mouse models and present TRPC3 as an emerging candidate protein implicated in various forms of ataxia in humans. Springer-Verlag Berlin Heidelberg, 2015 Cerebellum nationallicence Purkinje cell nationallicence mGluR1 nationallicence STIM1 nationallicence Ataxia nationallicence Hartmann Jana Institute of Neuroscience, Technische Universität München, Biedersteiner Str. 29, 80802, Munich, Germany aut Konnerth Arthur Institute of Neuroscience, Technische Universität München, Biedersteiner Str. 29, 80802, Munich, Germany aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/9(2015-09-01), 983-989 0946-2716 93:9<983 2015 93 109 https://doi.org/10.1007/s00109-015-1298-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1298-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hartmann Jana Institute of Neuroscience, Technische Universität München, Biedersteiner Str. 29, 80802, Munich, Germany aut NATIONALLICENCE 700 1- Konnerth Arthur Institute of Neuroscience, Technische Universität München, Biedersteiner Str. 29, 80802, Munich, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/9(2015-09-01), 983-989 0946-2716 93:9<983 2015 93 109