Generation of cardiac progenitor cells through epicardial to mesenchymal transition
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| 024 | 7 | 0 | |a 10.1007/s00109-015-1290-2 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00109-015-1290-2 | ||
| 245 | 0 | 0 | |a Generation of cardiac progenitor cells through epicardial to mesenchymal transition |h [Elektronische Daten] |c [Antonia Germani, Eleonora Foglio, Maurizio Capogrossi, Matteo Russo, Federica Limana] |
| 520 | 3 | |a The epithelial to mesenchymal transition (EMT) is a biological process that drives the formation of cells involved both in tissue repair and in pathological conditions, including tissue fibrosis and tumor metastasis by providing cancer cells with stem cell properties. Recent findings suggest that EMT is reactivated in the heart following ischemic injury. Specifically, epicardial EMT might be involved in the formation of cardiac progenitor cells (CPCs) that can differentiate into endothelial cells, smooth muscle cells, and, possibly, cardiomyocytes. The identification of mechanisms and signaling pathways governing EMT-derived CPC generation and differentiation may contribute to the development of a more efficient regenerative approach for adult heart repair. Here, we summarize key literature in the field. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a EMT |2 nationallicence | |
| 690 | 7 | |a Epicardial cells |2 nationallicence | |
| 690 | 7 | |a Molecular rehabilitation |2 nationallicence | |
| 690 | 7 | |a Cardiac repair |2 nationallicence | |
| 700 | 1 | |a Germani |D Antonia |u Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy |4 aut | |
| 700 | 1 | |a Foglio |D Eleonora |u Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy |4 aut | |
| 700 | 1 | |a Capogrossi |D Maurizio |u Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy |4 aut | |
| 700 | 1 | |a Russo |D Matteo |u Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy |4 aut | |
| 700 | 1 | |a Limana |D Federica |u Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy |4 aut | |
| 773 | 0 | |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/7(2015-07-01), 735-748 |x 0946-2716 |q 93:7<735 |1 2015 |2 93 |o 109 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-015-1290-2 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00109-015-1290-2 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Germani |D Antonia |u Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Foglio |D Eleonora |u Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Capogrossi |D Maurizio |u Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Russo |D Matteo |u Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Limana |D Federica |u Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/7(2015-07-01), 735-748 |x 0946-2716 |q 93:7<735 |1 2015 |2 93 |o 109 | ||