caa a22 4500 60554316X CHVBK 20210128100925.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00109-015-1290-2 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1290-2 Generation of cardiac progenitor cells through epicardial to mesenchymal transition [Elektronische Daten] [Antonia Germani, Eleonora Foglio, Maurizio Capogrossi, Matteo Russo, Federica Limana] The epithelial to mesenchymal transition (EMT) is a biological process that drives the formation of cells involved both in tissue repair and in pathological conditions, including tissue fibrosis and tumor metastasis by providing cancer cells with stem cell properties. Recent findings suggest that EMT is reactivated in the heart following ischemic injury. Specifically, epicardial EMT might be involved in the formation of cardiac progenitor cells (CPCs) that can differentiate into endothelial cells, smooth muscle cells, and, possibly, cardiomyocytes. The identification of mechanisms and signaling pathways governing EMT-derived CPC generation and differentiation may contribute to the development of a more efficient regenerative approach for adult heart repair. Here, we summarize key literature in the field. Springer-Verlag Berlin Heidelberg, 2015 EMT nationallicence Epicardial cells nationallicence Molecular rehabilitation nationallicence Cardiac repair nationallicence Germani Antonia Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy aut Foglio Eleonora Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy aut Capogrossi Maurizio Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy aut Russo Matteo Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy aut Limana Federica Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/7(2015-07-01), 735-748 0946-2716 93:7<735 2015 93 109 https://doi.org/10.1007/s00109-015-1290-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1290-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Germani Antonia Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy aut NATIONALLICENCE 700 1- Foglio Eleonora Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy aut NATIONALLICENCE 700 1- Capogrossi Maurizio Laboratorio di Patologia Vascolare, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy aut NATIONALLICENCE 700 1- Russo Matteo Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy aut NATIONALLICENCE 700 1- Limana Federica Laboratorio di Patologia Cellulare e Molecolare, San Raffaele Pisana, IRCCS, Rome, Italy aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/7(2015-07-01), 735-748 0946-2716 93:7<735 2015 93 109