caa a22 4500 605543178 CHVBK 20210128100925.0 cr unu---uuuuu 210128e20150701xx s 000 0 eng 10.1007/s00109-015-1299-6 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1299-6 Hunter Kent Laboratory of Cancer Biology and Genetics, CCR/NCI/NIH, Building 37 Room 5046C, 37 Convent Drive, 20892-4264, Bethesda, MD, USA aut The role of individual inheritance in tumor progression and metastasis [Elektronische Daten] [Kent Hunter] Metastasis, the dissemination and growth of tumor cells at secondary sites, is the primary cause of patient mortality from solid tumors. Metastasis is an extremely complex, inefficient process requiring contributions of not only the tumor cell but also local and distant environmental factors, at both the cellular and molecular level. Variation in the function of any of the steps in the metastatic cascade may therefore have profound implications for the ultimate course of the disease. In addition to the somatic and cellular heterogeneity that can affect cancer outcome, an individual's specific ancestry or genetic background can also significantly influence metastatic progression. These inherited variants not only encoded for metastatic susceptibility but also provided a window to study critical factors that are not easily accessible with current technologies. Furthermore, investigations into inherited metastatic susceptibility enable identification of important molecular and cellular processes that are not subject to mutation and are consequently not detectable by standard cancer genome sequencing strategies. Incorporation of inherited variation into metastasis research therefore provides methods to more comprehensively investigate the etiology of the lethal consequences of tumor progression. Springer-Verlag Berlin Heidelberg (outside the USA), 2015 Metastasis nationallicence Solid tumors nationallicence Cancer-related deaths nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/7(2015-07-01), 719-725 0946-2716 93:7<719 2015 93 109 https://doi.org/10.1007/s00109-015-1299-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1299-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hunter Kent Laboratory of Cancer Biology and Genetics, CCR/NCI/NIH, Building 37 Room 5046C, 37 Convent Drive, 20892-4264, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/7(2015-07-01), 719-725 0946-2716 93:7<719 2015 93 109