caa a22 4500 605543291 CHVBK 20210128100926.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s00109-015-1320-0 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1320-0 Nlrp1 inflammasome is downregulated in trauma patients [Elektronische Daten] [B. Relja, J. Horstmann, K. Kontradowitz, K. Jurida, A. Schaible, C. Neunaber, E. Oppermann, I. Marzi] Springer-Verlag Berlin Heidelberg, 2015 Immune suppression nationallicence Monocytes nationallicence Inflammasome nationallicence Nlrp nationallicence AIS : Abbreviated injury scale nationallicence ASC : Apoptosis-associated speck-like protein containing CARD nationallicence BSA : Bovine serum albumin nationallicence CARD : Caspase activation and recruitment domain nationallicence CASP1 : Caspase-1 nationallicence CD : Cluster of differentiation nationallicence Ctrl : Control nationallicence DAMP : Damage-associated molecular pattern nationallicence ED : Emergency department nationallicence ELISA : Enzyme-linked immunosorbent assay nationallicence EDTA : Ethylenediaminetetraacetic acid nationallicence GAPDH : Glyceraldehyde 3-phosphate dehydrogenase nationallicence HV : Healthy volunteers nationallicence ICU : Intensive care unit nationallicence IL : Interleukin nationallicence ISS : Injury severity score nationallicence LRR : Leucin-rich repeats nationallicence LPS : Lipopolysaccharide nationallicence mRNA : Messenger ribonucleic acid nationallicence NLR : NOD-like receptor nationallicence Nlrp : NLR sensor molecule containing pyrin domaine nationallicence PBS : Phosphate-buffered saline nationallicence PAMPs : Pathogen-associated molecular pattern nationallicence PC : Plasmid ctrl nationallicence PRR : Pattern recognition receptors nationallicence PYCARD : Gene encoding for ASC nationallicence TP : Trauma patients nationallicence Relja B. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut Horstmann J. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut Kontradowitz K. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut Jurida K. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut Schaible A. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut Neunaber C. Trauma Department, Hannover Medical School, Hannover, Germany aut Oppermann E. Department of General and Visceral Surgery, Goethe University, Frankfurt, Germany aut Marzi I. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/12(2015-12-01), 1391-1400 0946-2716 93:12<1391 2015 93 109 https://doi.org/10.1007/s00109-015-1320-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1320-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Relja B. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Horstmann J. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Kontradowitz K. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Jurida K. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Schaible A. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Neunaber C. Trauma Department, Hannover Medical School, Hannover, Germany aut NATIONALLICENCE 700 1- Oppermann E. Department of General and Visceral Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 700 1- Marzi I. Department of Trauma, Hand and Reconstructive Surgery, Goethe University, Frankfurt, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/12(2015-12-01), 1391-1400 0946-2716 93:12<1391 2015 93 109