caa a22 4500 605543348 CHVBK 20210128100926.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00109-015-1254-6 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1254-6 Mitophagy and heart failure [Elektronische Daten] [Sarah Shires, Åsa Gustafsson] Cardiac mitochondria are responsible for generating energy in the form of ATP through oxidative phosphorylation and are crucial for cardiac function. Mitochondrial dysfunction is a major contributor to loss of myocytes and development of heart failure. Myocytes have quality control mechanisms in place to ensure a network of functional mitochondria. Damaged mitochondria are degraded by a process called mitochondrial autophagy, or mitophagy, where the organelle is engulfed by an autophagosome and subsequently delivered to a lysosome for degradation. Evidence suggests that mitophagy is important for cellular homeostasis, and reduced mitophagy leads to inadequate removal of dysfunctional mitochondria. In this review, we discuss the regulation of mitophagy and the emerging evidence of the cardioprotective role of mitophagy. We also address the prospect of therapeutically targeting mitophagy to treat patients with cardiovascular disease. Springer-Verlag Berlin Heidelberg, 2015 Mitophagy nationallicence Heart failure nationallicence Autophagy nationallicence Mitochondria nationallicence Shires Sarah Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, 92093-0758, La Jolla, CA, USA aut Gustafsson Åsa Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, 92093-0758, La Jolla, CA, USA aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 253-262 0946-2716 93:3<253 2015 93 109 https://doi.org/10.1007/s00109-015-1254-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1254-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shires Sarah Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, 92093-0758, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Gustafsson Åsa Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, 92093-0758, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 253-262 0946-2716 93:3<253 2015 93 109