caa a22 4500 605543399 CHVBK 20210128100926.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00109-014-1230-6 doi (NATIONALLICENCE)springer-10.1007/s00109-014-1230-6 MitoTimer: a novel protein for monitoring mitochondrial turnover in the heart [Elektronische Daten] [Roberta Gottlieb, Aleksandr Stotland] Mitochondrial quality control refers to the coordinated cellular systems involved in maintaining a population of healthy mitochondria. In addition to mitochondrial protein chaperones (Hsp10, Hsp60, and others) and proteases (Lon, AAA proteases) needed for refolding or degrading individual proteins, mitochondrial integrity is maintained through the regulation of protein import via the TOM/TIM complex and protein redistribution across the network via fusion and fission and through mitophagy and biogenesis, key determinants of mitochondrial turnover. A growing number of studies point to the importance of mitochondrial dynamics (fusion/fission) and mitochondrial autophagy in the heart. Mitochondrial biogenesis must keep pace with mitophagy in order to maintain a stable number of mitochondria. In this review, we will discuss the use of MitoTimer as a tool to monitor mitochondrial turnover. The Author(s), 2014 MitoTimer nationallicence Mitochondrial biogenesis nationallicence Mitophagy nationallicence Fluorescence microscopy nationallicence Gottlieb Roberta Heart Institute and Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd. AHSP9105, 90048, Los Angeles, CA, USA aut Stotland Aleksandr Heart Institute and Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd. AHSP9105, 90048, Los Angeles, CA, USA aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 271-278 0946-2716 93:3<271 2015 93 109 https://doi.org/10.1007/s00109-014-1230-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-014-1230-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gottlieb Roberta Heart Institute and Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd. AHSP9105, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Stotland Aleksandr Heart Institute and Barbra Streisand Women's Heart Center, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd. AHSP9105, 90048, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 271-278 0946-2716 93:3<271 2015 93 109