caa a22 4500 605543429 CHVBK 20210128100926.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00109-014-1237-z doi (NATIONALLICENCE)springer-10.1007/s00109-014-1237-z Frohman Michael Center for Developmental Genetics, Stony Brook University, 11794, Stony Brook, NY, USA aut Role of mitochondrial lipids in guiding fission and fusion [Elektronische Daten] [Michael Frohman] Clinically important links have been established between mitochondrial function and cardiac physiology and disease in the context of signaling mechanisms, energy production, and muscle cell development. The proteins and processes that drive mitochondrial fusion and fission are now known to have emergent functions in intracellular calcium homeostasis, apoptosis, vascular smooth muscle cell proliferation, myofibril organization, and Notch-driven cell differentiation, all key issues in cardiac disease. Moreover, decreasing fission may confer protection against ischemic heart disease, particularly in the setting of obesity, diabetes, and heart failure. The importance of lipids in controlling mitochondrial fission and fusion is increasingly becoming appreciated. Roles for the bulk and signaling lipids cardiolipin, phosphatidylethanolamine, phosphatidic acid, diacylglycerol, and lysophosphatidic acid and the enzymes that synthesize or metabolize them in the control of mitochondrial shape and function are reviewed here. A number of diseases have been linked to loss-of-function alleles for a subset of the enzymes, emphasizing the importance of the lipid environment in this context. Springer-Verlag Berlin Heidelberg, 2014 Mitochondria nationallicence Fission nationallicence Fusion nationallicence Cardiolipin nationallicence Phosphatidic acid nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 263-269 0946-2716 93:3<263 2015 93 109 https://doi.org/10.1007/s00109-014-1237-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-014-1237-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Frohman Michael Center for Developmental Genetics, Stony Brook University, 11794, Stony Brook, NY, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 263-269 0946-2716 93:3<263 2015 93 109