caa a22 4500 605543445 CHVBK 20210128100926.0 cr unu---uuuuu 210128e20150301xx s 000 0 eng 10.1007/s00109-015-1257-3 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1257-3 Sharp Willard Section of Emergency Medicine, Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 5068, 60637, Chicago, IL, USA aut Dynamin-related protein 1 as a therapeutic target in cardiac arrest [Elektronische Daten] [Willard Sharp] Despite improvements in cardiopulmonary resuscitation (CPR) quality, defibrillation technologies, and implementation of therapeutic hypothermia, less than 10% of out-of-hospital cardiac arrest (OHCA) victims survive to hospital discharge. New resuscitation therapies have been slow to develop, in part, because the pathophysiologic mechanisms critical for resuscitation are not understood. During cardiac arrest, systemic cessation of blood flow results in whole body ischemia. CPR and the restoration of spontaneous circulation (ROSC), both result in immediate reperfusion injury of the heart that is characterized by severe contractile dysfunction. Unlike diseases of localized ischemia/reperfusion (IR) injury (myocardial infarction and stroke), global IR injury of organs results in profound organ dysfunction with far shorter ischemic times. The two most commonly injured organs following cardiac arrest resuscitation, the heart and brain, are critically dependent on mitochondrial function. New insights into mitochondrial dynamics and the role of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) in apoptosis have made targeting these mechanisms attractive for IR therapy. In animal models, inhibiting Drp1 following IR injury or cardiac arrest confers protection to both the heart and brain. In this review, the relationship of the major mitochondrial fission protein Drp1 to ischemic changes in the heart and its targeting as a new therapeutic target following cardiac arrest are discussed. Springer-Verlag Berlin Heidelberg, 2015 Cardiac arrest nationallicence Therapeutic hypothermia nationallicence Mdivi-1 nationallicence Cardiopulmonary resuscitation (CPR) nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 243-252 0946-2716 93:3<243 2015 93 109 https://doi.org/10.1007/s00109-015-1257-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1257-3 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sharp Willard Section of Emergency Medicine, Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 5068, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/3(2015-03-01), 243-252 0946-2716 93:3<243 2015 93 109