Genetic and molecular alterations across medulloblastoma subgroups
| LEADER | caa a22 4500 | ||
|---|---|---|---|
| 001 | 605543550 | ||
| 003 | CHVBK | ||
| 005 | 20210128100927.0 | ||
| 007 | cr unu---uuuuu | ||
| 008 | 210128e20151001xx s 000 0 eng | ||
| 024 | 7 | 0 | |a 10.1007/s00109-015-1333-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00109-015-1333-8 | ||
| 245 | 0 | 0 | |a Genetic and molecular alterations across medulloblastoma subgroups |h [Elektronische Daten] |c [Patryk Skowron, Vijay Ramaswamy, Michael Taylor] |
| 520 | 3 | |a Medulloblastoma is the most common malignant brain tumour diagnosed in children. Over the last few decades, advances in radiation and chemotherapy have significantly improved the odds of survival. Nevertheless, one third of all patients still succumb to their disease, and many long-term survivors are afflicted with neurocognitive sequelae. Large-scale multi-institutional efforts have provided insight into the transcriptional and genetic landscape of medulloblastoma. Four distinct subgroups of medulloblastoma have been identified, defined by distinct transcriptomes, genetics, demographics and outcomes. Integrated genomic profiling of each of these subgroups has revealed distinct genetic alterations, driving pathways and in some instances cells of origin. In this review, we highlight, in a subgroup-specific manner, our current knowledge of the genetic and molecular alterations in medulloblastoma and underscore the possible avenues for future therapeutic intervention. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Medulloblastoma |2 nationallicence | |
| 690 | 7 | |a Molecular genetics |2 nationallicence | |
| 690 | 7 | |a Therapy |2 nationallicence | |
| 690 | 7 | |a Subgroups |2 nationallicence | |
| 700 | 1 | |a Skowron |D Patryk |u Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |4 aut | |
| 700 | 1 | |a Ramaswamy |D Vijay |u Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |4 aut | |
| 700 | 1 | |a Taylor |D Michael |u Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |4 aut | |
| 773 | 0 | |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/10(2015-10-01), 1075-1084 |x 0946-2716 |q 93:10<1075 |1 2015 |2 93 |o 109 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-015-1333-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00109-015-1333-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Skowron |D Patryk |u Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Ramaswamy |D Vijay |u Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Taylor |D Michael |u Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/10(2015-10-01), 1075-1084 |x 0946-2716 |q 93:10<1075 |1 2015 |2 93 |o 109 | ||