caa a22 4500 605543550 CHVBK 20210128100927.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s00109-015-1333-8 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1333-8 Genetic and molecular alterations across medulloblastoma subgroups [Elektronische Daten] [Patryk Skowron, Vijay Ramaswamy, Michael Taylor] Medulloblastoma is the most common malignant brain tumour diagnosed in children. Over the last few decades, advances in radiation and chemotherapy have significantly improved the odds of survival. Nevertheless, one third of all patients still succumb to their disease, and many long-term survivors are afflicted with neurocognitive sequelae. Large-scale multi-institutional efforts have provided insight into the transcriptional and genetic landscape of medulloblastoma. Four distinct subgroups of medulloblastoma have been identified, defined by distinct transcriptomes, genetics, demographics and outcomes. Integrated genomic profiling of each of these subgroups has revealed distinct genetic alterations, driving pathways and in some instances cells of origin. In this review, we highlight, in a subgroup-specific manner, our current knowledge of the genetic and molecular alterations in medulloblastoma and underscore the possible avenues for future therapeutic intervention. Springer-Verlag Berlin Heidelberg, 2015 Medulloblastoma nationallicence Molecular genetics nationallicence Therapy nationallicence Subgroups nationallicence Skowron Patryk Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada aut Ramaswamy Vijay Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada aut Taylor Michael Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/10(2015-10-01), 1075-1084 0946-2716 93:10<1075 2015 93 109 https://doi.org/10.1007/s00109-015-1333-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1333-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Skowron Patryk Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Ramaswamy Vijay Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Taylor Michael Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/10(2015-10-01), 1075-1084 0946-2716 93:10<1075 2015 93 109