Role of sGC-dependent NO signalling and myocardial infarction risk
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| 024 | 7 | 0 | |a 10.1007/s00109-015-1265-3 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00109-015-1265-3 | ||
| 245 | 0 | 0 | |a Role of sGC-dependent NO signalling and myocardial infarction risk |h [Elektronische Daten] |c [Jana Wobst, Thorsten Kessler, Tan Dang, Jeanette Erdmann, Heribert Schunkert] |
| 520 | 3 | |a The NO/cGMP pathway plays an important role in many physiological functions and pathophysiological conditions. In the last few years, several genetic and functional studies pointed to an underestimated role of this pathway in the development of atherosclerosis. Indeed, several genetic variants of key enzymes modulating the generation of NO and cGMP have been strongly associated with coronary artery disease and myocardial infarction risk. In this review, we aim to place the genomic findings on components of the NO/cGMP pathway, namely endothelial nitric oxide synthase, soluble guanylyl cyclase and phosphodiesterase 5A, in context of preventive and therapeutic strategies for treating atherosclerosis and its sequelae. | |
| 540 | |a Springer-Verlag Berlin Heidelberg, 2015 | ||
| 690 | 7 | |a Myocardial infarction (MI) |2 nationallicence | |
| 690 | 7 | |a Coronary artery disease (CAD) |2 nationallicence | |
| 690 | 7 | |a Nitric oxide (NO)/cyclic guanosine-3′,5′-monophosphate (cGMP) pathway |2 nationallicence | |
| 690 | 7 | |a l -arginine-NOS pathway |2 nationallicence | |
| 690 | 7 | |a Nitrate-nitrite-NO pathway |2 nationallicence | |
| 690 | 7 | |a Nitric oxide synthases (NOS) |2 nationallicence | |
| 690 | 7 | |a Soluble guanylyl cyclase (sGC) |2 nationallicence | |
| 690 | 7 | |a Phosphodiesterase 5 (PDE5) |2 nationallicence | |
| 700 | 1 | |a Wobst |D Jana |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | |
| 700 | 1 | |a Kessler |D Thorsten |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | |
| 700 | 1 | |a Dang |D Tan |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | |
| 700 | 1 | |a Erdmann |D Jeanette |u Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany |4 aut | |
| 700 | 1 | |a Schunkert |D Heribert |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | |
| 773 | 0 | |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/4(2015-04-01), 383-394 |x 0946-2716 |q 93:4<383 |1 2015 |2 93 |o 109 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-015-1265-3 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00109-015-1265-3 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Wobst |D Jana |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Kessler |D Thorsten |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Dang |D Tan |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Erdmann |D Jeanette |u Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, Lübeck, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Schunkert |D Heribert |u Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/4(2015-04-01), 383-394 |x 0946-2716 |q 93:4<383 |1 2015 |2 93 |o 109 | ||