Cancer genomics: why rare is valuable
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| 024 | 7 | 0 | |a 10.1007/s00109-015-1260-8 |2 doi |
| 035 | |a (NATIONALLICENCE)springer-10.1007/s00109-015-1260-8 | ||
| 245 | 0 | 0 | |a Cancer genomics: why rare is valuable |h [Elektronische Daten] |c [Farzad Jamshidi, Torsten Nielsen, David Huntsman] |
| 520 | 3 | |a Rare conditions are sometimes ignored in biomedical research because of difficulties in obtaining specimens and limited interest from fund raisers. However, the study of rare diseases such as unusual cancers has again and again led to breakthroughs in our understanding of more common diseases. It is therefore unsurprising that with the development and accessibility of next-generation sequencing, much has been learnt from studying cancers that are rare and in particular those with uniform biological and clinical behavior. Herein, we describe how shotgun sequencing of cancers such as granulosa cell tumor, endometrial stromal sarcoma, epithelioid hemangioendothelioma, ameloblastoma, small-cell carcinoma of the ovary, clear-cell carcinoma of the ovary, nonepithelial ovarian tumors, chondroblastoma, and giant cell tumor of the bone has led to rapidly translatable discoveries in diagnostics and tumor taxonomies, as well as providing insights into cancer biology. | |
| 540 | |a The Author(s), 2015 | ||
| 690 | 7 | |a Next-generation sequencing |2 nationallicence | |
| 690 | 7 | |a Formefruste |2 nationallicence | |
| 690 | 7 | |a Rare tumors |2 nationallicence | |
| 690 | 7 | |a Genomics |2 nationallicence | |
| 700 | 1 | |a Jamshidi |D Farzad |u Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada |4 aut | |
| 700 | 1 | |a Nielsen |D Torsten |u Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada |4 aut | |
| 700 | 1 | |a Huntsman |D David |u Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada |4 aut | |
| 773 | 0 | |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/4(2015-04-01), 369-381 |x 0946-2716 |q 93:4<369 |1 2015 |2 93 |o 109 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-015-1260-8 |q text/html |z Onlinezugriff via DOI |
| 898 | |a BK010053 |b XK010053 |c XK010000 | ||
| 900 | 7 | |a Metadata rights reserved |b Springer special CC-BY-NC licence |2 nationallicence | |
| 908 | |D 1 |a review-article |2 jats | ||
| 949 | |B NATIONALLICENCE |F NATIONALLICENCE |b NL-springer | ||
| 950 | |B NATIONALLICENCE |P 856 |E 40 |u https://doi.org/10.1007/s00109-015-1260-8 |q text/html |z Onlinezugriff via DOI | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Jamshidi |D Farzad |u Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Nielsen |D Torsten |u Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 700 |E 1- |a Huntsman |D David |u Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada |4 aut | ||
| 950 | |B NATIONALLICENCE |P 773 |E 0- |t Journal of Molecular Medicine |d Springer Berlin Heidelberg |g 93/4(2015-04-01), 369-381 |x 0946-2716 |q 93:4<369 |1 2015 |2 93 |o 109 | ||