caa a22 4500 605543615 CHVBK 20210128100927.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s00109-015-1260-8 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1260-8 Cancer genomics: why rare is valuable [Elektronische Daten] [Farzad Jamshidi, Torsten Nielsen, David Huntsman] Rare conditions are sometimes ignored in biomedical research because of difficulties in obtaining specimens and limited interest from fund raisers. However, the study of rare diseases such as unusual cancers has again and again led to breakthroughs in our understanding of more common diseases. It is therefore unsurprising that with the development and accessibility of next-generation sequencing, much has been learnt from studying cancers that are rare and in particular those with uniform biological and clinical behavior. Herein, we describe how shotgun sequencing of cancers such as granulosa cell tumor, endometrial stromal sarcoma, epithelioid hemangioendothelioma, ameloblastoma, small-cell carcinoma of the ovary, clear-cell carcinoma of the ovary, nonepithelial ovarian tumors, chondroblastoma, and giant cell tumor of the bone has led to rapidly translatable discoveries in diagnostics and tumor taxonomies, as well as providing insights into cancer biology. The Author(s), 2015 Next-generation sequencing nationallicence Formefruste nationallicence Rare tumors nationallicence Genomics nationallicence Jamshidi Farzad Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada aut Nielsen Torsten Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada aut Huntsman David Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/4(2015-04-01), 369-381 0946-2716 93:4<369 2015 93 109 https://doi.org/10.1007/s00109-015-1260-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1260-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jamshidi Farzad Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Nielsen Torsten Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 700 1- Huntsman David Genetic Pathology Evaluation Centre, University of British Columbia, Vancouver, BC, Canada aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/4(2015-04-01), 369-381 0946-2716 93:4<369 2015 93 109