caa a22 4500 605543712 CHVBK 20210128100928.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s00109-015-1314-y doi (NATIONALLICENCE)springer-10.1007/s00109-015-1314-y Cardiac fibroblasts: from development to heart failure [Elektronische Daten] [Thomas Moore-Morris, Nuno Guimarães-Camboa, Katherine Yutzey, Michel Pucéat, Sylvia Evans] Cardiac fibroblasts are a major cell population of the heart and are characterized by their capacity to produce extracellular matrix (ECM). In hearts subjected to pressure overload, excessive fibroblast accumulation is responsible for fibrosis of the myocardium, a major clinical issue. Hence, understanding mechanisms generating fibroblasts in this context has become a key question in the cardiovascular field. Recent studies now point to the activation of resident fibroblasts as the underlying cause of fibrosis. However, de novo generation of fibroblasts from endothelium and circulating hematopoietic cells has also been proposed to significantly contribute to fibrosis. Here, we discuss the latest findings on fibroblast origins, with a particular emphasis on the pressure overload model, and the implication of these findings for the development of anti-fibrotic therapies that are currently lacking. Springer-Verlag Berlin Heidelberg, 2015 Cardiac fibroblast nationallicence Hypertrophy nationallicence Fibrosis nationallicence Moore-Morris Thomas INSERM UMR_S910, GMGF, University Aix-Marseille, Marseille, France aut Guimarães-Camboa Nuno Skaggs School of Pharmacy, University of California San Diego, La Jolla, CA, USA aut Yutzey Katherine The Heart Institute, Division of Molecular Cardiovascular Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut Pucéat Michel INSERM UMR_S910, GMGF, University Aix-Marseille, Marseille, France aut Evans Sylvia Skaggs School of Pharmacy, University of California San Diego, La Jolla, CA, USA aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/8(2015-08-01), 823-830 0946-2716 93:8<823 2015 93 109 https://doi.org/10.1007/s00109-015-1314-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1314-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moore-Morris Thomas INSERM UMR_S910, GMGF, University Aix-Marseille, Marseille, France aut NATIONALLICENCE 700 1- Guimarães-Camboa Nuno Skaggs School of Pharmacy, University of California San Diego, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Yutzey Katherine The Heart Institute, Division of Molecular Cardiovascular Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Pucéat Michel INSERM UMR_S910, GMGF, University Aix-Marseille, Marseille, France aut NATIONALLICENCE 700 1- Evans Sylvia Skaggs School of Pharmacy, University of California San Diego, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/8(2015-08-01), 823-830 0946-2716 93:8<823 2015 93 109