caa a22 4500 605543798 CHVBK 20210128100928.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s00109-015-1274-2 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1274-2 Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome [Elektronische Daten] [Jayasri Nanduri, Ying-Jie Peng, Guoxiang Yuan, Ganesh Kumar, Nanduri Prabhakar] Systemic hypertension is one of the most prevalent cardiovascular diseases. Sleep-disordered breathing (SDB) with recurrent apnea is a major risk factor for developing essential hypertension. Chronic intermittent hypoxia (CIH) is a hallmark manifestation of recurrent apnea. Rodent models patterned after the O2 profiles seen with SDB patients showed that CIH is the major stimulus for causing systemic hypertension. This article reviews the physiological and molecular basis of CIH-induced hypertension. Physiological studies have identified that augmented carotid body chemosensory reflex and the resulting increase in sympathetic nerve activity are major contributors to CIH-induced hypertension. Analysis of molecular mechanisms revealed that CIH activates hypoxia-inducible factor (HIF)-1 and suppresses HIF-2-mediated transcription. Dysregulation of HIF-1- and HIF-2-mediated transcription leads to imbalance of pro-oxidant and anti-oxidant enzyme gene expression resulting in increased reactive oxygen species (ROS) generation in the chemosensory reflex which is central for developing hypertension. Springer-Verlag Berlin Heidelberg, 2015 Carotid body nationallicence Sensory long-term facilitation nationallicence NADPH oxidase nationallicence Superoxide dismutase nationallicence Oxidative stress nationallicence Nanduri Jayasri Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut Peng Ying-Jie Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut Yuan Guoxiang Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut Kumar Ganesh Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut Prabhakar Nanduri Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/5(2015-05-01), 473-480 0946-2716 93:5<473 2015 93 109 https://doi.org/10.1007/s00109-015-1274-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1274-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nanduri Jayasri Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut NATIONALLICENCE 700 1- Peng Ying-Jie Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut NATIONALLICENCE 700 1- Yuan Guoxiang Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut NATIONALLICENCE 700 1- Kumar Ganesh Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut NATIONALLICENCE 700 1- Prabhakar Nanduri Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Science Division, University of Chicago, 60615, Chicago, IL, USA aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/5(2015-05-01), 473-480 0946-2716 93:5<473 2015 93 109