caa a22 4500 60554395X CHVBK 20210128100929.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s00109-014-1241-3 doi (NATIONALLICENCE)springer-10.1007/s00109-014-1241-3 Protective role of autophagy and autophagy-related protein 5 in early tumorigenesis [Elektronische Daten] [He Liu, Zhaoyue He, Hans-Uwe Simon] Autophagy, a fundamental cellular catabolic process, is involved in the development of numerous diseases including cancer. Autophagy seems to have an ambivalent impact on tumor development. While increasing evidence indicates a cytoprotective role for autophagy that can contribute to resistance against chemotherapy and even against the adverse, hypoxic environment of established tumors, relatively few publications focus on the role of autophagy in early tumorigenesis. However, the consensus is that autophagy is inhibitory for the genesis of tumors. To understand this apparent contradiction, more detailed information about the roles of the individual participants in autophagy is needed. This review will address this topic with respect to autophagy-related protein 5 (ATG5), which in several lines of investigation has been ascribed special significance in the autophagic pathway. Furthermore, it was recently shown that an ATG5 deficiency in melanocytes interferes with oncogene-induced senescence, thus promoting melanoma tumorigenesis. Similarly, an ATG5 deficiency resulted in tumors of the lung and liver in experimental mouse models. Taken together, these findings indicate that ATG5 and the autophagy to which it contributes are essential gatekeepers restricting early tumorigenesis in multiple tissues. Springer-Verlag Berlin Heidelberg, 2014 Adenoma nationallicence Autophagy nationallicence ATG5 nationallicence Melanoma nationallicence Oncogenesis nationallicence Senescence nationallicence Tumorigenesis nationallicence Liu He Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, 3010, Bern, Switzerland aut He Zhaoyue Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, 3010, Bern, Switzerland aut Simon Hans-Uwe Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, 3010, Bern, Switzerland aut Journal of Molecular Medicine Springer Berlin Heidelberg 93/2(2015-02-01), 159-164 0946-2716 93:2<159 2015 93 109 https://doi.org/10.1007/s00109-014-1241-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-014-1241-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu He Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, 3010, Bern, Switzerland aut NATIONALLICENCE 700 1- He Zhaoyue Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, 3010, Bern, Switzerland aut NATIONALLICENCE 700 1- Simon Hans-Uwe Institute of Pharmacology, University of Bern, Friedbuehlstrasse 49, 3010, Bern, Switzerland aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/2(2015-02-01), 159-164 0946-2716 93:2<159 2015 93 109