caa a22 4500 605544018 CHVBK 20210128100929.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s00109-015-1351-6 doi (NATIONALLICENCE)springer-10.1007/s00109-015-1351-6 Sleeman Jonathan Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim (CBTM), University of Heidelberg, TRIDOMUS-Gebäude Haus C, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany aut The lymph node pre-metastatic niche [Elektronische Daten] [Jonathan Sleeman] Lymph node metastases occur frequently during the progression of many types of cancer, and their presence often reflects poor prognosis. The drainage of tumor-derived factors such as antigens, growth factors, cytokines, and exosomes through the lymphatic system to the regional lymph nodes plays an important role in the pre-metastatic conditioning of the microenvironment in lymph nodes, making them receptive and supportive metastatic niches for disseminating tumor cells. Modified immunological responses and remodeling of the vasculature are the most studied tumor-induced pre-metastatic changes in the lymph node microenvironment that promote metastasis, although other metastasis-relevant alterations are also starting to be studied. Here, I review our current understanding of the lymph node pre-metastatic niche, how tumors condition this niche, and the relevance of this conditioning for our understanding of the process of metastasis. Springer-Verlag Berlin Heidelberg, 2015 Lymph node nationallicence Metastasis nationallicence Metastatic niche nationallicence Disseminated tumor cell nationallicence Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1173-1184 0946-2716 93:11<1173 2015 93 109 https://doi.org/10.1007/s00109-015-1351-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00109-015-1351-6 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sleeman Jonathan Medical Faculty Mannheim, Centre for Biomedicine and Medical Technology Mannheim (CBTM), University of Heidelberg, TRIDOMUS-Gebäude Haus C, Ludolf-Krehl-Str. 13-17, 68167, Mannheim, Germany aut NATIONALLICENCE 773 0- Journal of Molecular Medicine Springer Berlin Heidelberg 93/11(2015-11-01), 1173-1184 0946-2716 93:11<1173 2015 93 109